Quorum Sensing Related Cyclic Dipeptides from Marine Actinomycetes

Title
Quorum Sensing Related Cyclic Dipeptides from Marine Actinomycetes
Author(s)
유병철; 이희승; 신희재
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2007-11-08
Abstract
As marine environmental conditions are extremely different from terrestrial ones, it is surmised that marine actinomycetes have different characteristics from those of terrestrial counterparts and, therefore, might produce different types of bioactive compounds. In our ongoing research to develop the biomedical potential from marine actinomycetes, we isolated six cyclic-dipeptides (diketopiperazines, DKPs) from marine actinomycetes and identified as proline-based DKPs. DKPs are connected with two amino acids, formed lactam structure, and discovered as metabolites of various bacteria and fungi. Also, DKPs possess powerful and useful biological activities including anticancer and antimicrobial activities. Recently, it was reported that one of DKPs is related with quorum sensing. Bacterial cells can communicate with each other via small diffusible signal molecules, a process commonly termed quorum sensing. One out of six DKPs was isolated as a quorum sensing signal molecule, and two of DKPs were connected by two D-amino acids, which is rare in nature. The structural characterization of the DKPs and their biological activities will be discussed in this presentation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30227
Bibliographic Citation
Preccedings of the Convention of the Pharmaceutical Society of Korea, pp.336, 2007
Publisher
The Pharmaceutical Society of Korea
Type
Conference
Language
English
Publisher
The Pharmaceutical Society of Korea
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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