Gene Expression Profile in Iprobenfos Exposed Medaka Fish by Microarray Analysis

Title
Gene Expression Profile in Iprobenfos Exposed Medaka Fish by Microarray Analysis
Author(s)
우선옥; 손성희; 류재천; 염승식
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2008-06-22
Abstract
Differential gene expression profiling was carried out in the hepatic tissue of medaka fish, Oryzias latipes, after exposure to an organophosphorus pesticide (OPP), Iprobenfos (IBP), a widely used pesticide in agri- and fish-culture, using a medaka cDNA microarray. Twenty six kinds of differentially expressed candidate genes, with 15 and 11 induced and repressed in their gene expressions, respectively, were associated with cytoskeleton (3.8%), development (7.7%), immune (7.7%), metabolism (30.8%), nucleic acid/protein binding (42.3%) and reproduction (7.7%). Of these genes, changes at the transcription level of five were re-evaluated by real-time quantitative PCR (qRT-PCR). Considering the known function of authentic genes, the effects of IBP on the biological activity and pathological aspects in medaka fish were discussed. The identified genes could be used as molecular biomarkers for biological responses to OPPs contamination in an aquatic environment.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29879
Bibliographic Citation
Society of Toxicologic Pathology 27th Annual symposium, pp.114, 2008
Publisher
Society of Toxicologic Pathology
Type
Conference
Language
English
Publisher
Society of Toxicologic Pathology
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