고해상도 GC분석을 통한 PCBs의 생태위해성 평가

Title
고해상도 GC분석을 통한 PCBs의 생태위해성 평가
Alternative Title
Ecological Risk Assessment Using High Resolution Analysis of Polychlorinated Biphenyls (PCBs)
Author(s)
Kannan; G. Petrick
Alternative Author(s)
Kannan
Publication Year
2009-01-01
Abstract
Polychlorinated biphenyls (PCBs) are complex mixture of ubiquitous, persistent, bioaccumulative toxic substances. Congener specific determination of this mixture demands high resolution (against co-contaminants and coeluants), sensitivity and accuracy. Analytical methodology using high resolution cleanup and multi dimensional chromatography with electron capture detection (MDGC-ECD) was applied to archived samples of flat fish, a flightless bird (Penguin), a flying bird (Razorbill) and seal. Thus the determined concentrations, represented in pg/mg fat, ranged from as low as 88 to as high as 32,000. The actual levels (mean) were: flat fish: 152; penguin (n = 2): 321; razorbill (n = 2): 576 and seal (n = 7): 7645. Target organisms accumulated several of the toxic non-, mono-, and di-ortho Cl substituted congeners including the most toxic 3,3',4,4'5-pentachlorobiphenyl (IUPAC = 126) in their body fat. Toxic Equivalents (TEQs) were calculated and reported as follows (fg/mg TEQ fat): flat fish: 70; penguin (n = 2): 68; razorbill (n = 2): 1600; and seal (n = 7): 635. Metabolic index for each PCB congener was calculated in seal based on X/153 ratio. This index revealed metabolism of several persistent congeners indicating induction of both Cytochrome P450 CYP IA and IIB enzymes. This congener-specific analysis of PCBs revealed the ecological stress in aquatic organisms from land based anthropogenic contamination.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29628
Bibliographic Citation
Interdisciplinary Studies on Environmental Chemistry — Environmental Research in Asia, pp.99 - 109, 2009
Publisher
TERRAPUB, Japan
Type
Conference
Language
English
Publisher
TERRAPUB, Japan
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