New Angiogenesis Inhibitors from Marine-Derived Actinomycetes

Title
New Angiogenesis Inhibitors from Marine-Derived Actinomycetes
Author(s)
신희재; 이희승; 권호정
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2009-06-25
Abstract
Marine microbial natural products continue to represent an important source of novel compounds for the development of new therapeutic agents. As part of our ongoing research to isolate novel angiogenesis inhibitors, we have focused considerable attention on the marine actinomycetes. From the marine-derived actinomycetes, we could isolate several new angiogenesis inhibitors. Angiogenesis, a physical process involving the growth of new blood vessels from pre-existing vessels, is crucial for wound healing, embryonic development, and the female reproductive cycle, which is under elaborate regulations in normal vascular system. However, malignant angiogenesis plays a critical role in several fatal diseases including cancer, vascular insufficiency, diabetic retinopathy, and rheumatoid arthritis by a normal delivering mechanism of oxygen and nutrients to cell and tissue. Because tumor angiogenesis caused by angiogenic inducers is the most critical factor in the growth of solid tumors, as well as their invasion and metastasis, early control of angiogenesis may be a promising therapeutic strategy for the related diseases. We present here the discovery of new angiogenesis inhibitors from marine‐derived actinomycetes. The isolation, structure determination, and anti‐angiogenesis activity of the compounds from marine actinomycetes will be presented.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29392
Bibliographic Citation
Tenth Tetrahedron Symposium, pp.223, 2009
Publisher
Elsevier
Type
Conference
Language
English
Publisher
Elsevier
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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