Chitosan silver nano composites (CAgNCs) as antibacterial agent against fish pathogenic Edwardsiella tarda
SCOPUS
KCI
-
Title
- Chitosan silver nano composites (CAgNCs) as antibacterial agent against fish pathogenic Edwardsiella tarda
-
Author(s)
- Dananjaya, S.H.S.; Godahewa, G.I.; Lee, Y.; Cho, J.; Lee, J.; De Zoysa, M.
- KIOST Author(s)
- Lee, Young Deuk(이영득)
-
Alternative Author(s)
- 이영득
-
Publication Year
- 2014
-
Abstract
- Recently nano particles have proven for wide array of bioactive properties. In the present study, antibacterial properties of chitosan silver nano composites (CAgNCs) were investigated against fish pathogenic Edwardsiella tarda. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of CAgNCs against E. tarda were 25 µg/mL and 125 µg/mL, respectively. The field emission scanning electron microscope (FE-SEM) image of CAgNCs treated E. tarda showed the strongly damaged bacteria cells than non-treated bacteria. Furthermore, treatment of CAgNCs induced the level of intracellular reactive oxygen species (ROS) in E. tarda cells in concentration and time dependent manner suggesting that it may generate oxidative stress leading to bacterial cell death. In addition, MTT assay results showed that the lowest cell viability at 100 µg/mL of CAgNCs treated E. tarda. Overall results of this study suggest that CAgNCs is a potential antibacterial agent to control pathogenic bacteria. © 2014, Korean Society of Veterinary Clinics. All rights reserved.
-
ISSN
- 1598-298X
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2937
-
Bibliographic Citation
- Journal of Veterinary Clinics, v.31, no.6, pp.502 - 506, 2014
-
Publisher
- Korean Society of Veterinary Clinics
-
Keywords
- Antimicrobial agents; Chitosan-silver nanocomposites; Edwardsiella tarda; Edwardsiellosis; Reactive oxygen species
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.