Gageotetrins A-C, Noncytotoxic Antimicrobial Linear Lipopeptides from a Marine Bacterium Bacillus subtilis SCIE SCOPUS

Cited 40 time in WEB OF SCIENCE Cited 38 time in Scopus
Title
Gageotetrins A-C, Noncytotoxic Antimicrobial Linear Lipopeptides from a Marine Bacterium Bacillus subtilis
Author(s)
Tareq, Fakir Shahidullah; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Hasan, Choudhury M.; Islam, Md Tofazzal; Shin, Hee Jae
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Soo(이종수)
Publication Year
2014-02-07
Abstract
Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 mu M. However, these compounds failed to register any cytotoxicity (GI(50) > 30 mu g/ml) against human cancer cell lines.
ISSN
1523-7060
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2901
DOI
10.1021/ol403657r
Bibliographic Citation
ORGANIC LETTERS, v.16, no.3, pp.928 - 931, 2014
Publisher
AMER CHEMICAL SOC
Subject
PHYTOPHTHORA-CAPSICI; DIVERSITY
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse