Transcriptional Changes Caused by Bisphenol A in Oryzias javanicus, a Fish Species Highly Adaptable to Environmental Salinity SCIE SCOPUS

Cited 9 time in WEB OF SCIENCE Cited 9 time in Scopus
Title
Transcriptional Changes Caused by Bisphenol A in Oryzias javanicus, a Fish Species Highly Adaptable to Environmental Salinity
Author(s)
Woo, Seonock; Denis, Vianney; Yum, Seungshic
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2014-02
Abstract
The Javanese medaka, Oryzias javanicus, is a fish highly adaptable to various environmental salinities. Here, we investigated the effects of the environmental pollutant bisphenol A (BPA; an endocrine disrupting chemical) on gene expression levels in this species acclimated to different salinities. Using cDNA microarrays, we detected the induction of differential expression of genes by BPA, and compared the transcriptional changes caused by chemical exposure at different salinities. There were marked transcriptional changes induced by BPA between treatments. While 533 genes were induced by a factor of more than two when O. javanicus was exposed to BPA in seawater, only 215 genes were induced in freshwater. Among those genes, only 78 were shared and changed significantly their expression in both seawater and freshwater. Those genes were mainly involved in cellular processes and signaling pathway. We then categorized by functional group genes specifically induced by BPA exposure in seawater or freshwater. Gene expression changes were further confirmed in O. javanicus exposed to various concentrations of BPA, using quantitative real-time reverse transcription PCR based on primer sets for 28 selected genes.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2870
DOI
10.3390/md12020983
Bibliographic Citation
Marine Drugs, v.12, no.2, pp.983 - 998, 2014
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
Oryzias javanicus; cDNA microarray; bisphenol A; gene expression; salinity
Type
Article
Language
English
Document Type
Article
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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