Neuroprotective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae against H2O2-Induced Oxidative Stress in Neuronal HT22 Cells

DC Field Value Language
dc.contributor.author 허수진 -
dc.contributor.author 오철홍 -
dc.contributor.author Abu Affan -
dc.contributor.author 예보람 -
dc.contributor.author 전선미 -
dc.contributor.author 권영경 -
dc.contributor.author 김태호 -
dc.contributor.author Seon-Heui Cha -
dc.contributor.author You-Jin Jeon -
dc.contributor.author 강도형 -
dc.date.accessioned 2020-07-16T18:48:04Z -
dc.date.available 2020-07-16T18:48:04Z -
dc.date.created 2020-02-11 -
dc.date.issued 2010-11-18 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/28518 -
dc.description.abstract The present study is designed to investigate the neuroprotective effect of a kind of phlorotannins, diphlorethohydroxycarmalol (DPHC) isolated from Ishige okrmurae against hydrogen peroxide (H2O2)-induced oxidative stress in HT22 murine hippocampal neuronal cells. H2O2 treatment induced neurotoxicity whereas DPHC prevented cells from H2O2-induced damage then restoring cell viability was significantly increased. Intracellular reactive oxygen species (ROS) and lipid peroxidation was overproduced as the result of the addition of H2O2, however, these ROS generation and lipid peroxidation was effectively inhibited by addition of DPHC in a dose-dependent manner. Moreover, DPHC suppressed the elevation of H2O2-induced Ca2+ release. These findings indicate that DPHC has neuroprotective effects against H2O2-induced damage in neuronal cells, and that an inhibitory effect on ROS production may contribute to the underlying mechanisms. -
dc.description.uri 1 -
dc.language English -
dc.publisher Korean Society of Marine Biotechnology -
dc.relation.isPartOf The 6th KSMB Annual Meeting and International Mini-symposium -
dc.title Neuroprotective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae against H2O2-Induced Oxidative Stress in Neuronal HT22 Cells -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 106 -
dc.citation.startPage 106 -
dc.citation.title The 6th KSMB Annual Meeting and International Mini-symposium -
dc.contributor.alternativeName 허수진 -
dc.contributor.alternativeName 오철홍 -
dc.contributor.alternativeName Abu Affan -
dc.contributor.alternativeName 예보람 -
dc.contributor.alternativeName 전선미 -
dc.contributor.alternativeName 권영경 -
dc.contributor.alternativeName 김태호 -
dc.contributor.alternativeName 강도형 -
dc.identifier.bibliographicCitation The 6th KSMB Annual Meeting and International Mini-symposium, pp.106 -
dc.description.journalClass 1 -
Appears in Collections:
Jeju Research Institute > Jeju Marine Research Center > 2. Conference Papers
Jeju Research Institute > Jeju Bio Research Center > 2. Conference Papers
Jeju Research Institute > Tropical & Subtropical Research Center > 2. Conference Papers
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