Neuroprotective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae against H2O2-Induced Oxidative Stress in Neuronal HT22 Cells

Title
Neuroprotective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae against H2O2-Induced Oxidative Stress in Neuronal HT22 Cells
Author(s)
허수진; 오철홍; Abu Affan; 예보람; 전선미; 권영경; 김태호; Seon-Heui Cha; You-Jin Jeon; 강도형
KIOST Author(s)
Heo, Soo Jin(허수진)Oh, Chulhong(오철홍)Kim, Taeho(김태호)Kang, Do-Hyung(강도형)
Publication Year
2010-11-18
Abstract
The present study is designed to investigate the neuroprotective effect of a kind of phlorotannins, diphlorethohydroxycarmalol (DPHC) isolated from Ishige okrmurae against hydrogen peroxide (H2O2)-induced oxidative stress in HT22 murine hippocampal neuronal cells. H2O2 treatment induced neurotoxicity whereas DPHC prevented cells from H2O2-induced damage then restoring cell viability was significantly increased. Intracellular reactive oxygen species (ROS) and lipid peroxidation was overproduced as the result of the addition of H2O2, however, these ROS generation and lipid peroxidation was effectively inhibited by addition of DPHC in a dose-dependent manner. Moreover, DPHC suppressed the elevation of H2O2-induced Ca2+ release. These findings indicate that DPHC has neuroprotective effects against H2O2-induced damage in neuronal cells, and that an inhibitory effect on ROS production may contribute to the underlying mechanisms.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/28518
Bibliographic Citation
The 6th KSMB Annual Meeting and International Mini-symposium, pp.106, 2010
Publisher
Korean Society of Marine Biotechnology
Type
Conference
Language
English
Publisher
Korean Society of Marine Biotechnology
Related Researcher
Research Interests

Microalgae Culture and Application,Aquaculture System Engineering,미세조류 배양 및 응용,배양시스템 엔지니어링,유용해양생물 배양 및 응용

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