New Macrolactins as Antibiotics Produced by the Marine-derived Bacterium Bacillus sp. 102CH635-3

Title
New Macrolactins as Antibiotics Produced by the Marine-derived Bacterium Bacillus sp. 102CH635-3
Author(s)
이민아; 김지혜; TAREQ; 이희승; 이연주; 이종석; 신희재
KIOST Author(s)
Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
이민아; 김지혜; TAREQ; 이희승; 이연주; 이종석; 신희재
Publication Year
2012-04-20
Abstract
Marine microorganisms live in a quite different environment from their terrestrial counterparts and would thus be expected to have a different metabolic pathway and to produce compounds which prossess unique structures and activities. The macrolactins are a group of 24-membered lactones generally isolated from the deep sea bacteria1), Actinomadura sp.2) and Bacillus sp.3-5) The strain Bacillus sp. 102CH635-3 was isolated from a marine sediment sample collected from near Chuuk state in the Federated states of Micronesia(Fig. 1). Compounds 1-6 were purified from the EtOAc extract, obtained from the culture broth of the strain 102CH635-3(Fig. 2), by repeated choromatographic steps. Several studies have suggested that most macrolactins have potent bioactivities, such as antibacterial, cytotoxic and antiviral activities. The chemical stractures of 1-6 were elucidated on the basis of MS, 1D and 2D NMR spectroscopic data analysis and literature review. The macrolactins are a group of 24-membered lactones generally isolated from the deep sea bacteria1), Actinomadura sp.2) and Bacillus sp.3-5) The strain Bacillus sp. 102CH635-3 was isolated from a marine sediment sample collected from near Chuuk state in the Federated states of Micronesia(Fig. 1). Compounds 1-6 were purified from the EtOAc extract, obtained from the culture broth of the strain 102CH635-3(Fig. 2), by repeated choromatographic steps. Several studies have suggested that most macrolactins have potent bioactivities, such as antibacterial, cytotoxic and antiviral activities. The chemical stractures of 1-6 were elucidated on the basis of MS, 1D and 2D NMR spectroscopic data analysis and literature review.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27865
Bibliographic Citation
2012 약학연합국제학술대회, pp.358, 2012
Publisher
대한약학회
Type
Conference
Language
Korean
Publisher
대한약학회
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