Biologically-active indole containing compounds- natural products from sponges and their synthetic analogs
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Title
- Biologically-active indole containing compounds- natural products from sponges and their synthetic analogs
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Author(s)
- 이연주
- KIOST Author(s)
- Lee, Yeon Ju(이연주)
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Alternative Author(s)
- 이연주
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Publication Year
- 2012-05-24
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Abstract
- Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.ucts were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/27778
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Bibliographic Citation
- International Symposium on Marine Bioprospecting, pp.8, 2012
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Publisher
- Korea
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Type
- Conference
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Language
- English
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