Biologically-active indole containing compounds- natural products from sponges and their synthetic analogs

Title
Biologically-active indole containing compounds- natural products from sponges and their synthetic analogs
Author(s)
이연주
KIOST Author(s)
Lee, Yeon Ju(이연주)
Alternative Author(s)
이연주
Publication Year
2012-05-24
Abstract
Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.ucts were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27778
Bibliographic Citation
International Symposium on Marine Bioprospecting, pp.8, 2012
Publisher
Korea
Type
Conference
Language
English
Publisher
Korea
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