Cytotoxic 5-hydroxyindole alkaloids from the marine sponge Scalarispongia sp.

Title
Cytotoxic 5-hydroxyindole alkaloids from the marine sponge Scalarispongia sp.
Author(s)
이연주; 유수정; 신희재; 이종석; 이희승
KIOST Author(s)
Lee, Yeon Ju(이연주)Shin, Hee Jae(신희재)Lee, Jong Seok(이종석)Lee, Hyi Seung(이희승)
Alternative Author(s)
이연주; 유수정; 신희재; 이종석; 이희승
Publication Year
2012-06-26
Abstract
Three new 5-hydroxyindole alkaloids along with seven known analogs were isolated from a Dokdo marine sponge Scalarispongia sp.. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate, a mono-indole analog of hyrtinadine A, and a symmetrical bis-indole with pyridine linker. The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is an essential for the cytotoxicity.nds were an indole glyoxylate, a mono-indole analog of hyrtinadine A, and a symmetrical bis-indole with pyridine linker. The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is an essential for the cytotoxicity.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27626
Bibliographic Citation
13th tetrahedron symposium, pp.73, 2012
Publisher
elsevier
Type
Conference
Language
English
Publisher
elsevier
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