Cytotoxic 5-hydroxyindole alkaloids from the marine sponge Scalarispongia sp.
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Title
- Cytotoxic 5-hydroxyindole alkaloids from the marine sponge Scalarispongia sp.
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Author(s)
- 이연주; 유수정; 신희재; 이종석; 이희승
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Shin, Hee Jae(신희재); Lee, Jong Seok(이종석); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이연주; 유수정; 신희재; 이종석; 이희승
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Publication Year
- 2012-06-26
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Abstract
- Three new 5-hydroxyindole alkaloids along with seven known analogs were isolated from a Dokdo marine sponge Scalarispongia sp.. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate, a mono-indole analog of hyrtinadine A, and a symmetrical bis-indole with pyridine linker. The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is an essential for the cytotoxicity.nds were an indole glyoxylate, a mono-indole analog of hyrtinadine A, and a symmetrical bis-indole with pyridine linker. The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is an essential for the cytotoxicity.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/27626
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Bibliographic Citation
- 13th tetrahedron symposium, pp.73, 2012
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Publisher
- elsevier
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Type
- Conference
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Language
- English
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