Biological Control of Aeromonas salmonicida subsp. salmonicida Infection in Rainbow trout (Oncorhynchus mykiss) using Aeromonas Phage PAS-1
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Title
- Biological Control of Aeromonas salmonicida subsp. salmonicida Infection in Rainbow trout (Oncorhynchus mykiss) using Aeromonas Phage PAS-1
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Author(s)
- 김지형; Casiano H. Choresca; Sang Phil Shin; Jee Eun Han; Jin Woo Jun; 강도형; 오철홍; 허수진; Se Chang Park
- KIOST Author(s)
- Kang, Do Hyung(강도형); Oh, Chul Hong(오철홍); Heo, Soo Jin(허수진)
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Alternative Author(s)
- 김지형; 강도형; 오철홍; 허수진
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Publication Year
- 2012-11-08
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Abstract
- The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system related ascV gene, and a strong bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection, MOI: 10,000) in a rainbow trout-furunculosis model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/27408
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Bibliographic Citation
- 대한수의학회 2012년도 추계국제학술대회, pp.210, 2012
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Publisher
- 사단법인 대한수의학회
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Type
- Conference
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Language
- English
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