Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp. SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
Author(s)
Lee, Yeon-Ju; Lee, Jeong-Woo; Lee, Dong-Geun; Lee, Hyi-Seung; Kang, Jong Soon; Yun, Jieun
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2014-11
Abstract
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 mu M) against six human cancer cell lines.
ISSN
1422-0067
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2683
DOI
10.3390/ijms151120045
Bibliographic Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.15, no.11, pp.20045 - 20053, 2014
Publisher
MDPI
Keywords
sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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