Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
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Title
- Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
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Author(s)
- Lee, Yeon-Ju; Lee, Jeong-Woo; Lee, Dong-Geun; Lee, Hyi-Seung; Kang, Jong Soon; Yun, Jieun
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이연주; 이정우; 이동근; 이희승
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Publication Year
- 2014-11
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Abstract
- Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 mu M) against six human cancer cell lines.
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ISSN
- 1422-0067
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2683
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DOI
- 10.3390/ijms151120045
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Bibliographic Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.15, no.11, pp.20045 - 20053, 2014
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Publisher
- MDPI
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Keywords
- sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
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Type
- Article
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Language
- English
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Document Type
- Article
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