Anticancer and antioxidant effects of selected Sri Lankan marine algae SCIE SCOPUS

Cited 16 time in WEB OF SCIENCE Cited 19 time in Scopus
Title
Anticancer and antioxidant effects of selected Sri Lankan marine algae
Author(s)
Lakmal, H. H. Chaminda; Samarakoon, Kalpa W.; Lee, WonWoo; Lee, Ji-Hyeok; Abeytunga, D. T. U.; Lee, Hyi-Seung; Jeon, You-Jin
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2014-12
Abstract
For the investigation of bioactive components from Sri Lankan seaweeds, three species of red algae (Chondrophycus ceylanicus, Gelidiella acerosa, Gracilaria corticata), two species of green algae (Chaetomorpha crassa, Caulerpa racemosa) and one species of brown algae (Sargassum cassifolium) were evaluated. For the bioactivity evaluations, total phenol content (TPC), free radical scavenging activity using electron spin resonance (ESR) spectroscopy and anticancer activity against different cancer cell lines including a human promyelocytic leukemia (HL-60), a human lung carcinoma (A549) and a mouse melanoma (B16F10) were assessed in vitro. Among the extracts, C. racemosa showed significantly higher radical scavenging activity against DPPH (34.34 %), alkyl (85.17 %) and hydroxyl radicals (81.16 %), respectively. The MIT assay confirmed that all the extracts were not cytotoxic at 50 and 100 mu g/mL concentrations against vero cells in vitro. In addition, a significant cancer cell growth inhibitory effect (IC50 value 30.17 mu g/mL) was observed by C. racemosa methanol extract against HL-60 cells and it was the highest anticancer effect compared to the other extracts. Apoptotic body formation in HL-60 cells and the accumulation of DNA in sub-G(1) phase were determined by C. racemosa extract in a dose-dependent manner. This study is the first report of Sri Lankan seaweeds with the potential of pharmacological effects including antioxidant and anticancer activity in vitro.
ISSN
1391-4588
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2651
DOI
10.4038/jnsfsr.v42i4.7730
Bibliographic Citation
JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA, v.42, no.4, pp.315 - 323, 2014
Publisher
NATL SCIENCE FOUNDATION SRI LANKA
Subject
RED ALGA; APOPTOSIS
Keywords
Anticancer activity; apoptosis; HL-60; in vitro; Sri Lankan seaweeds
Type
Article
Language
English
Document Type
Article
Publisher
NATL SCIENCE FOUNDATION SRI LANKA
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