Ieodomycin B와 Analogs의 효율적인 합성법

DC Field Value Language
dc.contributor.author 설재희 -
dc.contributor.author 이종석 -
dc.contributor.author 박솔 -
dc.contributor.author 이희승 -
dc.contributor.author 이연주 -
dc.contributor.author 신희재 -
dc.date.accessioned 2020-07-16T05:51:32Z -
dc.date.available 2020-07-16T05:51:32Z -
dc.date.created 2020-02-11 -
dc.date.issued 2014-04-16 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/26378 -
dc.description.abstract Marine-derived microorganisms are increasingly recognized as the true metabolic sources of marinenatural products with therapeutic and pharmaceutical importance.Ieodomycin B is among the fourunsaturated fatty acids discovered from bioassay-guided isolation of the culture extract of a marine Bacillus sp. 09ID194 obtained from sediment in Ieodo, Republic of Koreas southern reef. As part of our on-going program for the discovery of bioactive substances from marine organisms and the subsequent construct of marine natural product-based small molecular library, it was an urgent need to develop an efficient synthesis of ieodomycins for material supply. Herein we describe the efficient syntheses of ieodomycin B and its analogs using (1) Ti-catalyzed asymmetric allylation of an aldehyde. (2) Stereoselective iodolactonization. (3) Completion of the synthesis of ieodomycin B and its analogs by coupling of various allyl tributyltin compounds with the corresponding iodolactone.say-guided isolation of the culture extract of a marine Bacillus sp. 09ID194 obtained from sediment in Ieodo, Republic of Koreas southern reef. As part of our on-going program for the discovery of bioactive substances from marine organisms and the subsequent construct of marine natural product-based small molecular library, it was an urgent need to develop an efficient synthesis of ieodomycins for material supply. Herein we describe the efficient syntheses of ieodomycin B and its analogs using (1) Ti-catalyzed asymmetric allylation of an aldehyde. (2) Stereoselective iodolactonization. (3) Completion of the synthesis of ieodomycin B and its analogs by coupling of various allyl tributyltin compounds with the corresponding iodolactone. -
dc.description.uri 2 -
dc.language English -
dc.publisher 대한화학회 -
dc.relation.isPartOf The 113th General Meeting of the Korean Chemical Society -
dc.title Ieodomycin B와 Analogs의 효율적인 합성법 -
dc.title.alternative Efficient Syntheses of Ieodomycin B and Its Analogs -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 59 -
dc.citation.startPage 59 -
dc.citation.title The 113th General Meeting of the Korean Chemical Society -
dc.contributor.alternativeName 설재희 -
dc.contributor.alternativeName 이종석 -
dc.contributor.alternativeName 박솔 -
dc.contributor.alternativeName 이희승 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 신희재 -
dc.identifier.bibliographicCitation The 113th General Meeting of the Korean Chemical Society, pp.59 -
dc.description.journalClass 2 -
Appears in Collections:
Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 2. Conference Papers
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