Ieodomycin B와 Analogs의 효율적인 합성법
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 설재희 | - |
dc.contributor.author | 이종석 | - |
dc.contributor.author | 박솔 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 이연주 | - |
dc.contributor.author | 신희재 | - |
dc.date.accessioned | 2020-07-16T05:51:32Z | - |
dc.date.available | 2020-07-16T05:51:32Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2014-04-16 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/26378 | - |
dc.description.abstract | Marine-derived microorganisms are increasingly recognized as the true metabolic sources of marinenatural products with therapeutic and pharmaceutical importance.Ieodomycin B is among the fourunsaturated fatty acids discovered from bioassay-guided isolation of the culture extract of a marine Bacillus sp. 09ID194 obtained from sediment in Ieodo, Republic of Koreas southern reef. As part of our on-going program for the discovery of bioactive substances from marine organisms and the subsequent construct of marine natural product-based small molecular library, it was an urgent need to develop an efficient synthesis of ieodomycins for material supply. Herein we describe the efficient syntheses of ieodomycin B and its analogs using (1) Ti-catalyzed asymmetric allylation of an aldehyde. (2) Stereoselective iodolactonization. (3) Completion of the synthesis of ieodomycin B and its analogs by coupling of various allyl tributyltin compounds with the corresponding iodolactone.say-guided isolation of the culture extract of a marine Bacillus sp. 09ID194 obtained from sediment in Ieodo, Republic of Koreas southern reef. As part of our on-going program for the discovery of bioactive substances from marine organisms and the subsequent construct of marine natural product-based small molecular library, it was an urgent need to develop an efficient synthesis of ieodomycins for material supply. Herein we describe the efficient syntheses of ieodomycin B and its analogs using (1) Ti-catalyzed asymmetric allylation of an aldehyde. (2) Stereoselective iodolactonization. (3) Completion of the synthesis of ieodomycin B and its analogs by coupling of various allyl tributyltin compounds with the corresponding iodolactone. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 대한화학회 | - |
dc.relation.isPartOf | The 113th General Meeting of the Korean Chemical Society | - |
dc.title | Ieodomycin B와 Analogs의 효율적인 합성법 | - |
dc.title.alternative | Efficient Syntheses of Ieodomycin B and Its Analogs | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 59 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | The 113th General Meeting of the Korean Chemical Society | - |
dc.contributor.alternativeName | 설재희 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.contributor.alternativeName | 박솔 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.contributor.alternativeName | 이연주 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.identifier.bibliographicCitation | The 113th General Meeting of the Korean Chemical Society, pp.59 | - |
dc.description.journalClass | 2 | - |