Transcriptome dynamics in Hydra after exposed to three pain relievers

Title
Transcriptome dynamics in Hydra after exposed to three pain relievers
Author(s)
염승식; 우선옥
KIOST Author(s)
Yum, Seungshic(염승식)
Publication Year
2014-05-12
Abstract
Pharmaceuticals and Personal Care Products (PPCPs) are substances used by individuals for personal health or cosmetic reasons and used by agribusiness to enhance growth or health of livestock. Among them, the pharmaceuticals that we take are not entirely absorbed by our bodies, and are excreted and passed into wastewater and surface water. In this study, the transcriptional responses against to exposure of three pain relievers, Diclofenac, Naproxen, and Ibuprofen, in Hydra were evaluated. For all three drugs, the median lethal concentrations of the animals (LC50) were determined. To define the repertoire of Hydra genes responding to acute exposure of three pain relievers, transcriptome dynamics were examined in a series of exposure time (6 h, 24 h and 48 h) by using 17 K Hydra Expressed Gene Microarray (HEGEM) which contains about 17,000 singletons of hydra genes. The gene ontology analysis was carried out for the differentially expressed genes after exposed to the three kinds of pain relievers.e not entirely absorbed by our bodies, and are excreted and passed into wastewater and surface water. In this study, the transcriptional responses against to exposure of three pain relievers, Diclofenac, Naproxen, and Ibuprofen, in Hydra were evaluated. For all three drugs, the median lethal concentrations of the animals (LC50) were determined. To define the repertoire of Hydra genes responding to acute exposure of three pain relievers, transcriptome dynamics were examined in a series of exposure time (6 h, 24 h and 48 h) by using 17 K Hydra Expressed Gene Microarray (HEGEM) which contains about 17,000 singletons of hydra genes. The gene ontology analysis was carried out for the differentially expressed genes after exposed to the three kinds of pain relievers.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/26277
Bibliographic Citation
2014 EURO SETAC, pp.230, 2014
Publisher
SETAC
Type
Conference
Language
English
Publisher
SETAC
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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