Sargachromanol G Isolated from Sargassum siliquastrum Inhibits Inflammatory Activity in RAW 264.7 Cells
DC Field | Value | Language |
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dc.contributor.author | 김민선 | - |
dc.contributor.author | 예보람 | - |
dc.contributor.author | 장지이 | - |
dc.contributor.author | 이아름 | - |
dc.contributor.author | 윤원종 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2020-07-16T04:32:50Z | - |
dc.date.available | 2020-07-16T04:32:50Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2014-06-20 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/26152 | - |
dc.description.abstract | A study on the anti-inflammatory activity of brown alga Sargassum siliquastrum led to the isolation of sargachromanol G (SG). In this study, the anti-inflammatory effect and the action mechanism of SG have been investigated in murine macrophage cell line RAW 264.7. SG dosedependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] induced by LPS treatment. To further elucidate the mechanism of this inhibitory effect of SG, we studied LPSinduced nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinases (MAPKs) phosphorylation. SG inhibited the phosphorylation IκB-α and NF-κB (p65 and p50) and MAPK (ERK1/2, JNK, and p38) in a dose dependent manner. These results suggest that the anti-inflammatory activity of SG results from its modulation of pro-inflammatory cytokines and mediators via the suppression of NF-κB activation and MAPK phosphorylation.hage cell line RAW 264.7. SG dosedependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] induced by LPS treatment. To further elucidate the mechanism of this inhibitory effect of SG, we studied LPSinduced nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinases (MAPKs) phosphorylation. SG inhibited the phosphorylation IκB-α and NF-κB (p65 and p50) and MAPK (ERK1/2, JNK, and p38) in a dose dependent manner. These results suggest that the anti-inflammatory activity of SG results from its modulation of pro-inflammatory cytokines and mediators via the suppression of NF-κB activation and MAPK phosphorylation. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | 한국응용생명화학회 | - |
dc.relation.isPartOf | KSABC | - |
dc.title | Sargachromanol G Isolated from Sargassum siliquastrum Inhibits Inflammatory Activity in RAW 264.7 Cells | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 215 | - |
dc.citation.startPage | 215 | - |
dc.citation.title | KSABC | - |
dc.contributor.alternativeName | 김민선 | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 장지이 | - |
dc.contributor.alternativeName | 이아름 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | KSABC, pp.215 | - |
dc.description.journalClass | 1 | - |