Apoptosis-Inducing Activity of Marine Sponge Haliclona sp Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 11 time in Scopus
Title
Apoptosis-Inducing Activity of Marine Sponge Haliclona sp Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells
Author(s)
Bae, Woori; Lim, Hyun Kyung; Kim, Kyoung Mee; Cho, Hyosun; Lee, Sun Yi; Jeong, Choon-Sik; Lee, Hyi-Seung; Jung, Joohee
KIOST Author(s)
Lee, Hyi Seung(이희승)
Alternative Author(s)
이희승
Publication Year
2015
Abstract
Although various anticancer drugs have been developed for the treatment of nonsmall cell lung cancer, chemotherapeutic efficacy is still limited. Natural products such as phytochemicals have been screened as novel alternative materials, but alternative funds such as marine bioresources remain largely untapped. Of these resources, marine sponges have undergone the most scrutiny for their biological activities, including antiinflammatory, antiviral, and anticancer properties. However, the biological mechanisms of the activities of these marine sponges are still unclear. We investigated the anticancer activity of marine sponges collected from Kosrae in Micronesia and examined their mechanisms of action using nonsmall cell lung cancer A549 cells as a model system. Of 20 specimens, the Haliclona sp. (KO1304-328) showed both dose-and time-dependent cytotoxicity. Further, methanol extracts of Haliclona sp. significantly inhibited cell proliferation and cell viability. A549 cells treated with Haliclona sp. demonstrated induced expression of c-Jun N-terminal kinase (JNK), p53, p21, caspase-8, and caspase-3. The percentage of apoptotic cells significantly increased in A549 cultures treated with Haliclona sp. These results indicate that Haliclona sp. induces apoptosis via the JNK-p53 pathway and caspase-8, suggesting that this marine sponge is a good resource for the development of drugs for treatment of nonsmall cell lung cancer.
ISSN
1741-427X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2615
DOI
10.1155/2015/717959
Bibliographic Citation
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015
Publisher
HINDAWI LTD
Subject
PROLIFERATION; P53
Type
Article
Language
English
Document Type
Article
Publisher
HINDAWI LTD
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