Cytotoxic Psammaplysin Analogs from Marine Sponge Suberea sp. and Role of Spirooxepinisoxazoline Ring in Their Activity

Title
Cytotoxic Psammaplysin Analogs from Marine Sponge Suberea sp. and Role of Spirooxepinisoxazoline Ring in Their Activity
Author(s)
이연주; 한샘; 이희승
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2014-10-29
Abstract
Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from the Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives and the other four were ceratinamine derivatives. Of the compounds obtained, psammaplysins exhibited high cytotoxicity against human cancer cell lines (GI50 values down to 0.8 μM), while ceratinamine and moloka’iamine analogs showed almost no activity. These results suggest that the spirooxepinisoxazoline ring is a requirement for cytotoxicity, and therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.ives. Of the compounds obtained, psammaplysins exhibited high cytotoxicity against human cancer cell lines (GI50 values down to 0.8 μM), while ceratinamine and moloka’iamine analogs showed almost no activity. These results suggest that the spirooxepinisoxazoline ring is a requirement for cytotoxicity, and therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25888
Bibliographic Citation
15th Tetrahedron Symposium - Asia Edition, pp.63, 2014
Publisher
Elsevier
Type
Conference
Language
English
Publisher
Elsevier
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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