Anti-inflammatory effect of violapyrones B and C from a marine-derived Streptomyces sp SCOPUS KCI

DC Field Value Language
dc.contributor.author Lee, H.-S. -
dc.contributor.author An, B.-J. -
dc.contributor.author Kim, H.J. -
dc.contributor.author Cho, Y.H. -
dc.contributor.author Kim, D.I. -
dc.contributor.author Jang, J.Y. -
dc.contributor.author Kwak, J.H. -
dc.contributor.author Lee, H.-S. -
dc.contributor.author Lee, Y.-J. -
dc.contributor.author Lee, J.S. -
dc.contributor.author Shin, H.J. -
dc.date.accessioned 2020-04-20T03:55:17Z -
dc.date.available 2020-04-20T03:55:17Z -
dc.date.created 2020-01-28 -
dc.date.issued 2015 -
dc.identifier.issn 1226-3907 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/2585 -
dc.description.abstract Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted α-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to 25 μM. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C. © 2015, Korean Society of Pharmacognosy. All rights reserved. -
dc.description.uri 3 -
dc.language English -
dc.publisher Korean Society of Pharmacognosy -
dc.subject antiinflammatory agent -
dc.subject inducible nitric oxide synthase -
dc.subject lipopolysaccharide -
dc.subject unclassified drug -
dc.subject violapyrones B -
dc.subject violapyrones C -
dc.subject violapyrones H -
dc.subject violapyrones I -
dc.subject antibacterial activity -
dc.subject antiinflammatory activity -
dc.subject antineoplastic activity -
dc.subject Article -
dc.subject cell culture -
dc.subject cell viability -
dc.subject controlled study -
dc.subject down regulation -
dc.subject drug structure -
dc.subject in vitro study -
dc.subject inflammation -
dc.subject metabolite -
dc.subject MTT assay -
dc.subject nonhuman -
dc.subject protein expression -
dc.subject Streptomyces -
dc.title Anti-inflammatory effect of violapyrones B and C from a marine-derived Streptomyces sp -
dc.type Article -
dc.citation.endPage 254 -
dc.citation.startPage 251 -
dc.citation.title Natural Product Sciences -
dc.citation.volume 21 -
dc.citation.number 4 -
dc.contributor.alternativeName 이화선 -
dc.contributor.alternativeName 이희승 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 이종석 -
dc.contributor.alternativeName 신희재 -
dc.identifier.bibliographicCitation Natural Product Sciences, v.21, no.4, pp.251 - 254 -
dc.identifier.doi 10.20307/nps.2015.21.4.251 -
dc.identifier.scopusid 2-s2.0-84957867502 -
dc.type.docType Article -
dc.identifier.kciid ART002061739 -
dc.description.journalClass 3 -
dc.subject.keywordPlus antiinflammatory agent -
dc.subject.keywordPlus inducible nitric oxide synthase -
dc.subject.keywordPlus lipopolysaccharide -
dc.subject.keywordPlus unclassified drug -
dc.subject.keywordPlus violapyrones B -
dc.subject.keywordPlus violapyrones C -
dc.subject.keywordPlus violapyrones H -
dc.subject.keywordPlus violapyrones I -
dc.subject.keywordPlus antibacterial activity -
dc.subject.keywordPlus antiinflammatory activity -
dc.subject.keywordPlus antineoplastic activity -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus cell culture -
dc.subject.keywordPlus cell viability -
dc.subject.keywordPlus controlled study -
dc.subject.keywordPlus down regulation -
dc.subject.keywordPlus drug structure -
dc.subject.keywordPlus in vitro study -
dc.subject.keywordPlus inflammation -
dc.subject.keywordPlus metabolite -
dc.subject.keywordPlus MTT assay -
dc.subject.keywordPlus nonhuman -
dc.subject.keywordPlus protein expression -
dc.subject.keywordPlus Streptomyces -
dc.subject.keywordAuthor Anti-inflammatory -
dc.subject.keywordAuthor Streptomyces sp -
dc.subject.keywordAuthor Violapyrones -
dc.subject.keywordAuthor α-Pyrones -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
Appears in Collections:
Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 1. Journal Articles
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