Anti-inflammatory effect of violapyrones B and C from a marine-derived Streptomyces sp SCOPUS KCI

Title
Anti-inflammatory effect of violapyrones B and C from a marine-derived Streptomyces sp
Author(s)
Lee, H.-S.; An, B.-J.; Kim, H.J.; Cho, Y.H.; Kim, D.I.; Jang, J.Y.; Kwak, J.H.; Lee, H.-S.; Lee, Y.-J.; Lee, J.S.; Shin, H.J.
KIOST Author(s)
Lee, Hwa Sun(이화선)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
이화선; 이희승; 이연주; 이종석; 신희재
Publication Year
2015
Abstract
Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted α-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to 25 μM. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C. © 2015, Korean Society of Pharmacognosy. All rights reserved.
ISSN
1226-3907
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2585
DOI
10.20307/nps.2015.21.4.251
Bibliographic Citation
Natural Product Sciences, v.21, no.4, pp.251 - 254, 2015
Publisher
Korean Society of Pharmacognosy
Subject
antiinflammatory agent; inducible nitric oxide synthase; lipopolysaccharide; unclassified drug; violapyrones B; violapyrones C; violapyrones H; violapyrones I; antibacterial activity; antiinflammatory activity; antineoplastic activity; Article; cell culture; cell viability; controlled study; down regulation; drug structure; in vitro study; inflammation; metabolite; MTT assay; nonhuman; protein expression; Streptomyces
Keywords
Anti-inflammatory; Streptomyces sp; Violapyrones; α-Pyrones
Type
Article
Language
English
Document Type
Article
Publisher
Korean Society of Pharmacognosy
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