Construction of target-specific virus-like particles for the delivery of algicidal compounds to harmful algae SCIE SCOPUS

DC Field Value Language Kang, Beom Sik - Eom, Chi-Yong - Kim, Wonduck - Kim, Pyoung Il - Ju, Sun Yi - Ryu, Jaewon - Han, Gui Hwan - Oh, Jeong-Il - Cho, Hoon - Baek, Seung Ho - Kim, Gueeda - Kim, Minju - Hyun, Jaekyung - Jin, EonSeon - Kim, Si Wouk - 2020-04-20T03:40:39Z - 2020-04-20T03:40:39Z - 2020-01-28 - 2015-04 -
dc.identifier.issn 1462-2912 -
dc.identifier.uri -
dc.description.abstract Harmful algal blooms (HABs) can lead to substantial socio-economic losses and extensive damage to aquatic ecosystems, drinking water sources and human health. Common algicidal techniques, including ozonation, ultrasonic treatment and dispersion of algae-killing chemicals, are unsatisfactory both economically and ecologically. This study therefore presents a novel alternative strategy for the efficient control of deleterious algae via the use of host-specific virus-like particles (VLPs) combined with chemically synthesized algicidal compounds. The capsid protein of HcRNAV34, a single-stranded RNA virus that infects the toxic dinoflagellate, Heterocapsa circularisquama, was expressed in and purified from Escherichia coli and then self-assembled into VLPsin vitro. Next, the algicidal compound, thiazolidinedione 49 (TD49), was encapsidated into HcRNAV34 VLPs for specific delivery to H. circularisquama. Consequently, HcRNAV34 VLPs demonstrated the same host selectivity as naturally occurring HcRNAV34 virions, while TD49-encapsidated VLPs showed a more potent target-specific algicidal effect than TD49 alone. These results indicate that target-specific VLPs for the delivery of cytotoxic compounds to nuisance algae might provide a safe, environmentally friendly approach for the management of HABs in aquatic ecosystems. -
dc.description.uri 1 -
dc.language English -
dc.publisher WILEY -
dc.subject RNA VIRUS -
dc.subject CAPSID PROTEIN -
dc.subject RED TIDE -
dc.subject FLOCCULATION -
dc.subject HCRNAV -
dc.subject BLOOMS -
dc.subject CLAY -
dc.subject TD49 -
dc.title Construction of target-specific virus-like particles for the delivery of algicidal compounds to harmful algae -
dc.type Article -
dc.citation.endPage 1474 -
dc.citation.startPage 1463 -
dc.citation.volume 17 -
dc.citation.number 4 -
dc.identifier.bibliographicCitation ENVIRONMENTAL MICROBIOLOGY, v.17, no.4, pp.1463 - 1474 -
dc.identifier.doi 10.1111/1462-2920.12650 -
dc.identifier.scopusid 2-s2.0-84926417796 -
dc.identifier.wosid 000352545100040 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus RNA VIRUS -
dc.subject.keywordPlus CAPSID PROTEIN -
dc.subject.keywordPlus RED TIDE -
dc.subject.keywordPlus FLOCCULATION -
dc.subject.keywordPlus HCRNAV -
dc.subject.keywordPlus BLOOMS -
dc.subject.keywordPlus CLAY -
dc.subject.keywordPlus TD49 -
dc.relation.journalWebOfScienceCategory Microbiology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Microbiology -
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South Sea Research Institute > Risk Assessment Research Center > 1. Journal Articles
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