Anti-inflammatory Activities of Chromene Derivatives isolated from Sargassum siliquastrum in LPS-Stimulated RAW 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | 예보람 | - |
dc.contributor.author | 김민선 | - |
dc.contributor.author | 김준성 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2020-07-15T22:53:24Z | - |
dc.date.available | 2020-07-15T22:53:24Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2015-11-10 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/25081 | - |
dc.description.abstract | Chromene derivatives was isolated from Sargassum siliquastrum showed anti-inflammatory effects on pro-inflammatory mediators in LPS-stimulated murine macrophage RAW 264.7 cells. Chromene derivatives were identified as sargachromanol series, and its anti-inflammatory effects showed inhibitory activities of NO production. Especially, sargachromanol G (SG) showed its profound inhibitory effect. SG significantly inhibited the production of inflammatory markers (NO, iNOS, PGE2, and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a concentration-dependent manner. The anti-inflammatory effects dose-dependently inhibited the phosphorylation IкB-α and NF-кB (p65 and p50) and MAPK (ERK1/2, JNK, and p38). These results suggest that SG have the necessary properties to be used as an effective anti-inflammatory agent by the down-regulation of NF-кB activation and MAPK phosphorylation. and its anti-inflammatory effects showed inhibitory activities of NO production. Especially, sargachromanol G (SG) showed its profound inhibitory effect. SG significantly inhibited the production of inflammatory markers (NO, iNOS, PGE2, and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a concentration-dependent manner. The anti-inflammatory effects dose-dependently inhibited the phosphorylation IкB-α and NF-кB (p65 and p50) and MAPK (ERK1/2, JNK, and p38). These results suggest that SG have the necessary properties to be used as an effective anti-inflammatory agent by the down-regulation of NF-кB activation and MAPK phosphorylation. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | The Korean Society of Food Science and Nutrition | - |
dc.relation.isPartOf | 2015 KFN International Symposium and Auunual Meeting | - |
dc.title | Anti-inflammatory Activities of Chromene Derivatives isolated from Sargassum siliquastrum in LPS-Stimulated RAW 264.7 cells | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 384 | - |
dc.citation.startPage | 384 | - |
dc.citation.title | 2015 KFN International Symposium and Auunual Meeting | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 김민선 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | 2015 KFN International Symposium and Auunual Meeting, pp.384 | - |
dc.description.journalClass | 1 | - |