Anti-inflammatory Activities of Chromene Derivatives isolated from Sargassum siliquastrum in LPS-Stimulated RAW 264.7 cells

Title
Anti-inflammatory Activities of Chromene Derivatives isolated from Sargassum siliquastrum in LPS-Stimulated RAW 264.7 cells
Author(s)
예보람; 김민선; 김준성; 허수진
KIOST Author(s)
Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2015-11-10
Abstract
Chromene derivatives was isolated from Sargassum siliquastrum showed anti-inflammatory effects on pro-inflammatory mediators in LPS-stimulated murine macrophage RAW 264.7 cells. Chromene derivatives were identified as sargachromanol series, and its anti-inflammatory effects showed inhibitory activities of NO production. Especially, sargachromanol G (SG) showed its profound inhibitory effect. SG significantly inhibited the production of inflammatory markers (NO, iNOS, PGE2, and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a concentration-dependent manner. The anti-inflammatory effects dose-dependently inhibited the phosphorylation IкB-α and NF-кB (p65 and p50) and MAPK (ERK1/2, JNK, and p38). These results suggest that SG have the necessary properties to be used as an effective anti-inflammatory agent by the down-regulation of NF-кB activation and MAPK phosphorylation. and its anti-inflammatory effects showed inhibitory activities of NO production. Especially, sargachromanol G (SG) showed its profound inhibitory effect. SG significantly inhibited the production of inflammatory markers (NO, iNOS, PGE2, and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a concentration-dependent manner. The anti-inflammatory effects dose-dependently inhibited the phosphorylation IкB-α and NF-кB (p65 and p50) and MAPK (ERK1/2, JNK, and p38). These results suggest that SG have the necessary properties to be used as an effective anti-inflammatory agent by the down-regulation of NF-кB activation and MAPK phosphorylation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25081
Bibliographic Citation
2015 KFN International Symposium and Auunual Meeting, pp.384, 2015
Publisher
The Korean Society of Food Science and Nutrition
Type
Conference
Language
English
Publisher
The Korean Society of Food Science and Nutrition
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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