New Jaspamide Derivatives from the Tropical Marine Sponge Jaspis laingis

Title
New Jaspamide Derivatives from the Tropical Marine Sponge Jaspis laingis
Author(s)
엄태양; 유수정; 이연주; 이희승
KIOST Author(s)
Eom, Tae Yang(엄태양)Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2015-11-19
Abstract
Sponges are a rich source of bioactive natural products with significant drug development potential. Marine sponges of the genus Jaspis are known to be a prolific source of different classes of compounds. Among them, jaspamide is a class of natural depsipeptide that was first isolated from the jaspis sp.1 in 1986. To date 18 compounds of jaspamide family have been reported. Jaspamide class compounds are known for insecticidal, antifungal, antimicrofilament and cytotoxic activity. We now report two new jaspamide derivatives, these compounds have been isolated from the tropical sponge Jaspis laingi collected from Kosrae, federated states of micronesia. Two new derivatives are the first linear depsipeptide skeleton in family of jaspamide. Other linear depsipeptide analogue like dolastatin15 have been described.2 Bioassay- guided fractionation of an organic extract of this sponge using LH-20, RP-18 chromatography and HPLC led interestingly to the isolation of a new family of linear depsipeptides. The structures of these new metabolites were determined by combined spectroscopic and chemical methods and comparison with jsapamide.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25043
Bibliographic Citation
2015 한국해양바이오학회 학술발표회, pp.109, 2015
Publisher
한국해양바이오학회
Type
Conference
Language
English
Publisher
한국해양바이오학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse