해양 바실러스 서브틸리스 유래의 신규 가거테트린 유도체

Title
해양 바실러스 서브틸리스 유래의 신규 가거테트린 유도체
Alternative Title
New Gageotetrin Derivatives from a Marine Bacillus Subtilis 109GGC020
Author(s)
이화선; 안봉전; 최병규; 이희승; 이종석; 이연주; 이지훈; 신희재
KIOST Author(s)
Lee, Hwa Sun(이화선)Choi, Byeoung Kyu(최병규)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Lee, Jihoon(이지훈)
Publication Year
2016-11-25
Abstract
Marine microorganisms have received increased attention as a potential source for drug discovery because they produce structurally and functionally diverse bioactive compounds. Among them, marine Bacillus species produce various secondary metabolites including lipopeptides, macrolactones, fatty acids and polyketides. And these compounds have been reported to have a wide range of biological activities, such as antimicrobial, anticancer and anti-inflammatory activities.1 In previous our studies, linear lipopeptides, gageotetrins A-C having noncytotoxic anti-bacterial activities, were isolated from the culture broth of the strain 109GGC020.2 As part of our ongoing study for the discovery of the new compounds, we found three new gageotetrin derivatives from the fermentation broth of the Bacillus subtilis 109GGC020 by chromatographic methods. The structures and stereochemistry of the new derivatives were determined by spectroscopic data and chemical derivatization.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/24293
Bibliographic Citation
해양바이오학회 학술발표회, pp.1, 2016
Publisher
한국해양바이오학회
Type
Conference
Language
English
Publisher
한국해양바이오학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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