Meroterpenoids from a Tropical Dysidea sp Sponge
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Title
- Meroterpenoids from a Tropical Dysidea sp Sponge
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Author(s)
- Kim, Chang-Kwon; Woo, Jung-Kyun; Kim, Seong-Hwan; Cho, Eunji; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이연주; 이희승
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Publication Year
- 2015-11
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Abstract
- Six new meroterpenoids (16), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 46 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na+/K+-ATPase.
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2383
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DOI
- 10.1021/acs.jnatprod.5b00867
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.78, no.11, pp.2814 - 2821, 2015
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Publisher
- AMER CHEMICAL SOC
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Subject
- OKINAWAN MARINE SPONGE; SESQUITERPENOID QUINONES; INHIBITION; GROWTH; AMINOQUINONES; ILIMAQUINONE; METABOLITES; MEMBRANES; AVARONE; ASSAY
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Type
- Article
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Language
- English
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Document Type
- Article
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