Meroterpenoids from a Tropical Dysidea sp Sponge SCIE SCOPUS

Cited 25 time in WEB OF SCIENCE Cited 27 time in Scopus
Title
Meroterpenoids from a Tropical Dysidea sp Sponge
Author(s)
Kim, Chang-Kwon; Woo, Jung-Kyun; Kim, Seong-Hwan; Cho, Eunji; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2015-11
Abstract
Six new meroterpenoids (16), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 46 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na+/K+-ATPase.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2383
DOI
10.1021/acs.jnatprod.5b00867
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.78, no.11, pp.2814 - 2821, 2015
Publisher
AMER CHEMICAL SOC
Subject
OKINAWAN MARINE SPONGE; SESQUITERPENOID QUINONES; INHIBITION; GROWTH; AMINOQUINONES; ILIMAQUINONE; METABOLITES; MEMBRANES; AVARONE; ASSAY
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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