Gene expression changes in Fish Oryzias javanicus exposed to Fluoxetine

Title
Gene expression changes in Fish Oryzias javanicus exposed to Fluoxetine
Author(s)
Ade Yamindago; 조예진; 염승식
KIOST Author(s)
Jo, Yejin(조예진)Yum, Seungshic(염승식)
Publication Year
2017-12-12
Abstract
Fluoxetine is one of the most prescribed drugs to treat depression, panic, anxiety, or obsessive-compulsive symptoms. The effects of this drug were investigated in O. javanicus to predict biological processes associated with toxic responses in aquatic organism. The median lethal concentrations (LC50) of Fluoxetine in O. javanicus were 2.046±0.299 (24 h), 1.936±0.055 (48 h), 1.532±0.144 (72 h) and 1.237±0.160 mg/L (96 h). Transcriptomic analysis showed dynamic changes in the differentially expressed genes of O. javanicus exposed to Fluoxetine for 12, 24, 48 and 72 h. Functional annotation of the differentially expressed genes suggested that these genes were involved in respiratory depression associated with cell cycle arrest, oxidative stress inducing endoplasmic reticulum stress and protein damage, acute phases response associated with inflammatory responses and metabolic changes associated with changes in carbohydrate and lipid metabolisms. The genes associated with locomotory behavior were also affected in the exposed fish. Thus, this study extends understanding in toxic effect of human pharmaceutical product in environment. in aquatic organism. The median lethal concentrations (LC50) of Fluoxetine in O. javanicus were 2.046±0.299 (24 h), 1.936±0.055 (48 h), 1.532±0.144 (72 h) and 1.237±0.160 mg/L (96 h). Transcriptomic analysis showed dynamic changes in the differentially expressed genes of O. javanicus exposed to Fluoxetine for 12, 24, 48 and 72 h. Functional annotation of the differentially expressed genes suggested that these genes were involved in respiratory depression associated with cell cycle arrest, oxidative stress inducing endoplasmic reticulum stress and protein damage, acute phases response associated with inflammatory responses and metabolic changes associated with changes in carbohydrate and lipid metabolisms. The genes associated with locomotory behavior were also affected in the exposed fish. Thus, this study extends understanding in toxic effect of human pharmaceutical product in environment.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23517
Bibliographic Citation
International Conference Celebrating the 10th anniversary of KoEHS, pp.S32 - s32, 2017
Publisher
Korea Society of Environmental Risk Assessment and Health Science
Type
Conference
Language
English
Publisher
Korea Society of Environmental Risk Assessment and Health Science
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