섬유아세포성장인자의 분석을 통한 고래류의 수상 적응 연구

Title
섬유아세포성장인자의 분석을 통한 고래류의 수상 적응 연구
Alternative Title
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans
Author(s)
남기웅; 이경원; 정옥성; 임형순; 차선신; 이세원; 전제훈; 조윤성; 박종화
KIOST Author(s)
Lee, Kyeong Won(이경원)Yim, Hyung Soon(임형순)
Publication Year
2018-03-26
Abstract
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment.acean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23456
Bibliographic Citation
2018 Gordon Research Conferences Fibroblast Growth Factors in Development and Disease, 2018
Publisher
Gordon
Type
Conference
Language
English
Publisher
Gordon
Related Researcher
Research Interests

marine genomics,biochemistry,molecular cell biology,해양 유전체,생화학,세포분자 생물학

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