Genomic Properties of the Novel Natural Products producing Marine Bacterium Streptomyces sp. MEBiC10311

Title
Genomic Properties of the Novel Natural Products producing Marine Bacterium Streptomyces sp. MEBiC10311
Author(s)
오지혜; 김병권; 신희재; 권개경
KIOST Author(s)
Kwon, Kae Kyoung(권개경)
Publication Year
2018-04-27
Abstract
Genome of a Streptomyces strain was sequenced with PacBio RSII system SMRT sequencing technology and its genes related to the production of secondary metabolites were investigated via anti-SMASH web-based tool. Strain MEBiC10311 showed no difference with S. rutgersensis, S. gougerotii, and S. diabolicus in 16S rRNA gene sequence similarity, however, genome of strain MEBiC10311 was different from previously known strains with species level. Genome of strain MEBiC10311 was 7.28 Mbps size, 73.3 mol% of DNA G+C ratio, 5,882 CDS, and include 14 gene clusters related to the production of secondary metabolites. The clusters consisted with four NRPS, one type 1 PKS, 1 siderophore, and 7 PKS-NRPS hybrids. Among the 14 predicted products, 11 were novel from previously known compounds. This study revealed that small differences in the genome made novel differences in the production of natural products. [Supported grants from KIOST & MBRB].ifference with S. rutgersensis, S. gougerotii, and S. diabolicus in 16S rRNA gene sequence similarity, however, genome of strain MEBiC10311 was different from previously known strains with species level. Genome of strain MEBiC10311 was 7.28 Mbps size, 73.3 mol% of DNA G+C ratio, 5,882 CDS, and include 14 gene clusters related to the production of secondary metabolites. The clusters consisted with four NRPS, one type 1 PKS, 1 siderophore, and 7 PKS-NRPS hybrids. Among the 14 predicted products, 11 were novel from previously known compounds. This study revealed that small differences in the genome made novel differences in the production of natural products. [Supported grants from KIOST & MBRB].
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23415
Bibliographic Citation
2018한국미생물학회국제학술대회초록집, pp.37, 2018
Publisher
한국미생물학회
Type
Conference
Language
English
Publisher
한국미생물학회
Related Researcher
Research Interests

Acquisition of marine microbial bioresources,Marine microbial diversity,Application study on marine microbes,해양미생물 자원 확보,해양미생물 다양성,해양미생물 기능 활용

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