ANTI-INFLAMMATORY EFFECT OF SUPERCRITICAL EXTRACT AND ITS CONSTITUENTS FROM ISHIGE OKAMURAE SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Ko, Eun-Yi | - |
dc.contributor.author | Yoon, Weon-Jong | - |
dc.contributor.author | Lee, Hae-Won | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Ko, Young-Hwan | - |
dc.contributor.author | Fernando, I. P. Shanura | - |
dc.contributor.author | Cho, Kichul | - |
dc.contributor.author | Lee, Chi-Heon | - |
dc.contributor.author | Hur, Sung-Pyo | - |
dc.contributor.author | Cho, Su-Hyeon | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Kim, Daekyung | - |
dc.contributor.author | Kim, Kil-Nam | - |
dc.date.accessioned | 2020-04-20T02:55:40Z | - |
dc.date.available | 2020-04-20T02:55:40Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2324 | - |
dc.description.abstract | The anti-inflammatory properties of the supercritical fluid extract of Ishige okamurae (SFEIO) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. The lipid profile of the SFEIO, reviled the presence of palmitic acid (220.2 mg/g), linoleic acid (168.0 mg/g), and oleic acid (123.0 mg/g). SFEIO was found to exert it's anti-inflammatory effects through inhibiting nitric oxide (NO), prostaglandin E-2 (PGE(2)), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and IL-6 production in LPS-stimulated RAW 264.7 cells, without inducing cytotoxicity. SFEIO did not effect on the LPS-induced p38 kinase phosphorylation, whereas it attenuated the extracellular-related signaling kinase (ERK) and c-Jun N-terminal kinase (JNK) phosphorylation. Furthermore, SFEIO inhibited the LPS-induced I kappa B-alpha degradation and p50 NF-kappa B activation. These results suggest that SFEIO exerts its anti-inflammatory effects in LPSactivated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-kappa B. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | EXCLI JOURNAL MANAGING OFFICE | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | RAW 264.7 CELLS | - |
dc.subject | FATTY-ACIDS | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | MURINE MACROPHAGES | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | FLUID EXTRACTION | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | OLEIC-ACID | - |
dc.title | ANTI-INFLAMMATORY EFFECT OF SUPERCRITICAL EXTRACT AND ITS CONSTITUENTS FROM ISHIGE OKAMURAE | - |
dc.type | Article | - |
dc.citation.endPage | 445 | - |
dc.citation.startPage | 434 | - |
dc.citation.title | EXCLI JOURNAL | - |
dc.citation.volume | 15 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.contributor.alternativeName | 허성표 | - |
dc.identifier.bibliographicCitation | EXCLI JOURNAL, v.15, pp.434 - 445 | - |
dc.identifier.doi | 10.17179/excli2016-337 | - |
dc.identifier.scopusid | 2-s2.0-84984893045 | - |
dc.identifier.wosid | 000380189100003 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | RAW 264.7 CELLS | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | MURINE MACROPHAGES | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | FLUID EXTRACTION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | OLEIC-ACID | - |
dc.subject.keywordAuthor | supercritical fluid extraction | - |
dc.subject.keywordAuthor | linoleic acid | - |
dc.subject.keywordAuthor | Ishige okamurae | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |