Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia

Title
Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia
Author(s)
이연주; 김수현; 이희승; 이종석; 이지훈
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Jihoon(이지훈)
Publication Year
2018-08-20
Abstract
Three new sulfated steroidal glycosides, along with known cholesterol derivatives, were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The characteristic structural features of the new compounds include the sulfate group at the C-3 position and the xylose linked to C-7, which is different from those of known steroidal glycosides. The three new compounds were named as Conusaponin A-C, as these are the first example of steroidal glycosides isolated from Conus species. These compounds exhibited significant in vitro
cytotoxicity (GI50 values down to 0.5 μM) against the K562 human leukemia cell line. This finding, combined with those regarding the previously reported steroidal glycosides with potent activities against various cancer cell lines, would provide new insights into the structure-activity relationships of cytotoxic sulfated steroidal glycosides.pectroscopy and high-resolution mass spectrometry. The characteristic structural features of the new compounds include the sulfate group at the C-3 position and the xylose linked to C-7, which is different from those of known steroidal glycosides. The three new compounds were named as Conusaponin A-C, as these are the first example of steroidal glycosides isolated from Conus species. These compounds exhibited significant in vitro
cytotoxicity (GI50 values down to 0.5 μM) against the K562 human leukemia cell line. This finding, combined with those regarding the previously reported steroidal glycosides with potent activities against various cancer cell lines, would provide new insights into the structure-activity relationships of cytotoxic sulfated steroidal glycosides.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23164
Bibliographic Citation
American Chemical Society 256th National Meeting, pp.1, 2018
Publisher
ACS
Type
Conference
Language
English
Publisher
ACS
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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