Bioactive compounds from a marine yeast Cystobasidium benthicum isolated from deep-sea sediment

Abstract

Natural products and their derivatives have been recognized as a attractive source of drug discovery.1 In particular, microorganisms from the marine environment, a rich source of structurally unique bioactive metabolites, have produced a number of drug candidates.2 Among them, marine microbes from the deep-sea are relatively untapped reservoir of unique structural and biological diversity waiting to be discovered because of lack of technology and difficult to collect.3 In our continuing search for bioactive substances from deep-sea microorganisms, we encountered a marine-derived yeast Cystobasidium benthicum. This strain was isolated from a deep-sea sediment sample collected by a multicorer in the Indian Ocean in August, 2017. We report here the isolation of bioactive compounds from the ethyl acetate extract of culture broth of C. benthicum by chromatographic methods along with their structure determination by analysis of spectoscopic data.mber of drug candidates.2 Among them, marine microbes from the deep-sea are relatively untapped reservoir of unique structural and biological diversity waiting to be discovered because of lack of technology and difficult to collect.3 In our continuing search for bioactive substances from deep-sea microorganisms, we encountered a marine-derived yeast Cystobasidium benthicum. This strain was isolated from a deep-sea sediment sample collected by a multicorer in the Indian Ocean in August, 2017. We report here the isolation of bioactive compounds from the ethyl acetate extract of culture broth of C. benthicum by chromatographic methods along with their structure determination by analysis of spectoscopic data.