A new triterpenoid Saponin from the tropical marine sponge Lipastrotethya sp.
SCOPUS
KCI
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Title
- A new triterpenoid Saponin from the tropical marine sponge Lipastrotethya sp.
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Author(s)
- Eom, T.-Y.; Lee, Y.-J.; Lee, H.-S.
- KIOST Author(s)
- Eom, Tae Yang(엄태양); Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 엄태양; 이연주; 이희승
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Publication Year
- 2016
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Abstract
- Marine sponges have been a remarkably rich source of pharmacologically active and structurally diverse natural products. As a part of our continuing search for novel secondary metabolites of biomedical importance from marine invertebrate, we encountered the sponge Lipastrotethya sp. from Chuuk, Micronesia. The crude organic extract of this animal exhibited considerable cytotoxicity against the K562 cell line. Guided by the 1H NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new triterpene glycoside, along with ten known saponins of the sarasinoside class. The structure of this new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment. Among these metabolites, six compounds exhibited moderate cytotoxicity against ACHN, MDA-MB-231, NCI-H23 and NUGC-3 cell lines. © 2016, Korea Ocean Research and Development Institute. All rights reserved.
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ISSN
- 1598-141X
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2306
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DOI
- 10.4217/OPR.2016.38.4.287
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Bibliographic Citation
- Ocean and Polar Research, v.38, no.4, pp.287 - 294, 2016
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Publisher
- Korea Ocean Research and Development Institute
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Subject
- biotechnology; chemical compound; drug development; experimental study; medical geography; new record; secondary metabolite; sponge; Animalia; Invertebrata
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Keywords
- Lipastrotethya sp.; Marine sponge; Saponin; Sarasinoside
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Type
- Article
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Language
- Korean
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Document Type
- Article
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