A new triterpenoid Saponin from the tropical marine sponge Lipastrotethya sp. SCOPUS KCI

Title
A new triterpenoid Saponin from the tropical marine sponge Lipastrotethya sp.
Author(s)
Eom, T.-Y.; Lee, Y.-J.; Lee, H.-S.
KIOST Author(s)
Eom, Tae Yang(엄태양)Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2016
Abstract
Marine sponges have been a remarkably rich source of pharmacologically active and structurally diverse natural products. As a part of our continuing search for novel secondary metabolites of biomedical importance from marine invertebrate, we encountered the sponge Lipastrotethya sp. from Chuuk, Micronesia. The crude organic extract of this animal exhibited considerable cytotoxicity against the K562 cell line. Guided by the 1H NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new triterpene glycoside, along with ten known saponins of the sarasinoside class. The structure of this new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment. Among these metabolites, six compounds exhibited moderate cytotoxicity against ACHN, MDA-MB-231, NCI-H23 and NUGC-3 cell lines. © 2016, Korea Ocean Research and Development Institute. All rights reserved.
ISSN
1598-141X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2306
DOI
10.4217/OPR.2016.38.4.287
Bibliographic Citation
Ocean and Polar Research, v.38, no.4, pp.287 - 294, 2016
Publisher
Korea Ocean Research and Development Institute
Subject
biotechnology; chemical compound; drug development; experimental study; medical geography; new record; secondary metabolite; sponge; Animalia; Invertebrata
Keywords
Lipastrotethya sp.; Marine sponge; Saponin; Sarasinoside
Type
Article
Language
Korean
Document Type
Article
Publisher
Korea Ocean Research and Development Institute
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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