SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2 SCIE SCOPUS

DC Field Value Language
dc.contributor.author Choi, Hyeong Sim -
dc.contributor.author Kim, Min Kyoung -
dc.contributor.author Lee, Kangwook -
dc.contributor.author Lee, Kang Min -
dc.contributor.author Choi, Youn Kyung -
dc.contributor.author Shin, Yong Cheol -
dc.contributor.author Cho, Sung-Gook -
dc.contributor.author Ko, Seong-Gyu -
dc.date.accessioned 2020-04-20T02:55:12Z -
dc.date.available 2020-04-20T02:55:12Z -
dc.date.created 2020-01-28 -
dc.date.issued 2016-05 -
dc.identifier.issn 1949-2553 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/2273 -
dc.description.abstract Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability. Consistently, SH003 inhibited VEGF-stimulated vascular permeability in ears and back skins. Moreover, SH003 inhibited VEGF-induced VEGFR2-dependent signaling by blocking VEGF binding to VEGFR2. Therefore, our data conclude that SH003 represses tumor angiogenesis by inhibiting VEGF-induced VEGFR2 activation, and suggest that SH003 may be useful for treating cancer. -
dc.description.uri 1 -
dc.language English -
dc.publisher IMPACT JOURNALS LLC -
dc.title SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2 -
dc.type Article -
dc.citation.endPage 32979 -
dc.citation.startPage 32969 -
dc.citation.title ONCOTARGET -
dc.citation.volume 7 -
dc.citation.number 22 -
dc.contributor.alternativeName 최윤경 -
dc.identifier.bibliographicCitation ONCOTARGET, v.7, no.22, pp.32969 - 32979 -
dc.identifier.doi 10.18632/oncotarget.8808 -
dc.identifier.scopusid 2-s2.0-84973572497 -
dc.identifier.wosid 000377748500105 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus TRADITIONAL CHINESE MEDICINE -
dc.subject.keywordPlus ANGELICA-GIGAS NAKAI -
dc.subject.keywordPlus ASTRAGALUS-MEMBRANACEUS -
dc.subject.keywordPlus CANCER-TREATMENT -
dc.subject.keywordPlus ASIAN MEDICINE -
dc.subject.keywordPlus CHEMOTHERAPY -
dc.subject.keywordPlus DECURSIN -
dc.subject.keywordPlus COMBINATION -
dc.subject.keywordPlus MECHANISMS -
dc.subject.keywordPlus THERAPY -
dc.subject.keywordAuthor SH003 -
dc.subject.keywordAuthor tumor angiogenesis -
dc.subject.keywordAuthor VEGF -
dc.subject.keywordAuthor VEGFR2 -
dc.subject.keywordAuthor TCM -
dc.relation.journalWebOfScienceCategory Oncology -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Oncology -
dc.relation.journalResearchArea Cell Biology -
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