SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
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Title
- SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
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Author(s)
- Choi, Hyeong Sim; Kim, Min Kyoung; Lee, Kangwook; Lee, Kang Min; Choi, Youn Kyung; Shin, Yong Cheol; Cho, Sung-Gook; Ko, Seong-Gyu
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Alternative Author(s)
- 최윤경
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Publication Year
- 2016-05
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Abstract
- Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability. Consistently, SH003 inhibited VEGF-stimulated vascular permeability in ears and back skins. Moreover, SH003 inhibited VEGF-induced VEGFR2-dependent signaling by blocking VEGF binding to VEGFR2. Therefore, our data conclude that SH003 represses tumor angiogenesis by inhibiting VEGF-induced VEGFR2 activation, and suggest that SH003 may be useful for treating cancer.
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ISSN
- 1949-2553
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2273
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DOI
- 10.18632/oncotarget.8808
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Bibliographic Citation
- ONCOTARGET, v.7, no.22, pp.32969 - 32979, 2016
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Publisher
- IMPACT JOURNALS LLC
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Keywords
- SH003; tumor angiogenesis; VEGF; VEGFR2; TCM
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Type
- Article
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Language
- English
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Document Type
- Article
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