SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2 SCIE SCOPUS

Cited 13 time in WEB OF SCIENCE Cited 13 time in Scopus
Title
SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
Author(s)
Choi, Hyeong Sim; Kim, Min Kyoung; Lee, Kangwook; Lee, Kang Min; Choi, Youn Kyung; Shin, Yong Cheol; Cho, Sung-Gook; Ko, Seong-Gyu
Publication Year
2016-05
Abstract
Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability. Consistently, SH003 inhibited VEGF-stimulated vascular permeability in ears and back skins. Moreover, SH003 inhibited VEGF-induced VEGFR2-dependent signaling by blocking VEGF binding to VEGFR2. Therefore, our data conclude that SH003 represses tumor angiogenesis by inhibiting VEGF-induced VEGFR2 activation, and suggest that SH003 may be useful for treating cancer.
ISSN
1949-2553
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2273
DOI
10.18632/oncotarget.8808
Bibliographic Citation
ONCOTARGET, v.7, no.22, pp.32969 - 32979, 2016
Publisher
IMPACT JOURNALS LLC
Keywords
SH003; tumor angiogenesis; VEGF; VEGFR2; TCM
Type
Article
Language
English
Document Type
Article
Publisher
IMPACT JOURNALS LLC
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