Adverse Effects, Expression of the Bk-CYP3045C1 Gene, and Activation of the ERK Signaling Pathway in the Water Accommodated Fraction-Exposed Rotifer SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Won, Eun-Ji | - |
dc.contributor.author | Kim, Ryeo-Ok | - |
dc.contributor.author | Kang, Hye-Min | - |
dc.contributor.author | Kim, Hui-Su | - |
dc.contributor.author | Hwang, Dae-Sik | - |
dc.contributor.author | Han, Jeonghoon | - |
dc.contributor.author | Lee, Young Hwan | - |
dc.contributor.author | Hwang, Un-Ki | - |
dc.contributor.author | Zhou, Bingsheng | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.contributor.author | Lee, Jae-Seong | - |
dc.date.accessioned | 2020-04-20T02:55:11Z | - |
dc.date.available | 2020-04-20T02:55:11Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2016-06-07 | - |
dc.identifier.issn | 0013-936X | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2272 | - |
dc.description.abstract | To examine the deleterious effects of the water accommodated fraction (WAF) of crude oil, the growth curve, fecundity, and lifespan of the monogonont rotifer (Brachionus koreanus) were measured for 24 h in response to three different doses (0.2X, 0.4X, and 0.8X) of WAFs. A higher dose of WAFs significantly reduced the fecundity and lifespan. A rotifer 32K microarray chip showed that the Bk-CYP3045C1 gene had the highest expression. Of the 25 entire CYP genes, the Bk-CYP3045C1 gene showed a significant expression for different doses and times in response to WAFs and chemical components of WAFs (naphthalene and phenanthrene); also, glutathione S-transferase genes, ABC transporter, and other genes showed dose responses upon exposure to 80% WAF over time. Different doses of WAFs increased the oxidative stress with an induction of reactive oxygen species (ROS) and a depletion of glutathione (GSH). Exposure to WAFs did not show toxic effects on survivability in B. koreanus; however, toxicity to WAFs was shown when piperonyl butoxide, a potent inhibitor of cytochrome P450 (CYP) enzymes, was added. This toxicity was dose-dependent. After WAFs exposure, PERK was activated over time in response to WAFs, which suggests that WAFs can be activated by the p-ERK signaling pathway. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject | CRUDE-OIL | - |
dc.subject | BRACHIONUS-KOREANUS | - |
dc.subject | MONOGONONT ROTIFER | - |
dc.subject | CYTOCHROME-P450 CYP | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PROTEIN-KINASES | - |
dc.subject | DISPERSED OIL | - |
dc.subject | TOXICITY | - |
dc.subject | SPILL | - |
dc.title | Adverse Effects, Expression of the Bk-CYP3045C1 Gene, and Activation of the ERK Signaling Pathway in the Water Accommodated Fraction-Exposed Rotifer | - |
dc.type | Article | - |
dc.citation.endPage | 6035 | - |
dc.citation.startPage | 6025 | - |
dc.citation.title | ENVIRONMENTAL SCIENCE & TECHNOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 11 | - |
dc.contributor.alternativeName | 원은지 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL SCIENCE & TECHNOLOGY, v.50, no.11, pp.6025 - 6035 | - |
dc.identifier.doi | 10.1021/acs.est.6b01306 | - |
dc.identifier.scopusid | 2-s2.0-84973652331 | - |
dc.identifier.wosid | 000377629900072 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject.keywordPlus | CRUDE-OIL | - |
dc.subject.keywordPlus | BRACHIONUS-KOREANUS | - |
dc.subject.keywordPlus | MONOGONONT ROTIFER | - |
dc.subject.keywordPlus | CYTOCHROME-P450 CYP | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PROTEIN-KINASES | - |
dc.subject.keywordPlus | DISPERSED OIL | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | SPILL | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |