Anti-cancer effect of Tuberatolide B in MDA-MB-231 cells through induction of ROS and inhibition of STAT3 pathway

Title
Anti-cancer effect of Tuberatolide B in MDA-MB-231 cells through induction of ROS and inhibition of STAT3 pathway
Author(s)
박아름이; 김은아; 김준성; 강나래; 허수진
KIOST Author(s)
Park, Areumi(박아름이)Kim, Eun A(김은아)Kim, Junseong(김준성)Kang, Nalae(강나래)Heo, Soo Jin(허수진)
Publication Year
2019-06-25
Abstract
Tuberatolide B (TTB, C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of TTB remain unknown. In this study, we demonstrate that TTB inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. To examine the mechanism by which TTB suppresses cell growth, we determined the effect of TTB on apoptosis, ROS generation, DNA damage, and signal transduction. TTB induced ROSproduction in MDA-MB-231, A549, and HCT116 cells. Moreover, TTB enhanced DNA damage by inducing H2AX foci formation and the phosphorylation of DNA damage-related proteins such as Chk2 and H2AX. Furthermore, TTB selectively inhibited STAT3 activation, which resulted in a reduction in cyclin D1, MMP-9, survivin, VEGF, and IL-6. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, TTB suppresses cancer progression by promoting ROS-mediated inhibition of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22571
Bibliographic Citation
Pharmaceutics and Drug Delivery Systems, pp.88, 2019
Publisher
PDDS2019
Type
Conference
Language
English
Publisher
PDDS2019
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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