심해 퇴적물에서 분리된 곰팡이 Cystobasidium laryngis 유래의 항염 물질

Abstract

Marine microorganisms are recognized as an important source for drug discovery because they produce secondary metabolites with different skeleton and diverse bioactivities than terrestrial counterparts [1, 2]. Especially, marine microbes derived from the deep-sea are relatively untapped reservoir of metabolites with structural and biological diversity waiting to be discovered because of lack of technology and the difficulty of collecting samples [3]. In our continuing research for bioactive substances from deep-sea microorganisms, we encountered a marine-derived yeast-like fungus Cystobasidium laryngis isolated from a deep-sea sediment sample. Here, we report the fermentation, isolation, structure elucidation and anti-inflammatory activities of three new and four known phenazine derivatives produced by the deep-sea derived fungus C. laryngis.