Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kang, Min-Cheol | - |
dc.contributor.author | Ding, Yuling | - |
dc.contributor.author | Kim, Eun-A | - |
dc.contributor.author | Choi, Youn Kyung | - |
dc.contributor.author | De Araujo, Thiago | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Lee, Seung-Hong | - |
dc.date.accessioned | 2020-04-20T02:25:22Z | - |
dc.date.available | 2020-04-20T02:25:22Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2125 | - |
dc.description.abstract | Seaweed, a popular and abundant food ingredient mainly consumed in Asian countries, is a good source of bioactive compounds with anti-obesity effects. However, the anti-obesity effects of Sargassum thunbergii have not yet been established. In this study, we isolated six indole derivatives (STCs)-indole-2-carboxaldehyde (STC-1), indole-3-carboxaldehyde (STC-2), indole-4-carboxaldehyde (STC-3), indole-5-carboxaldehyde (STC-4), indole-6-carboxaldehyde (STC-5), and indole-7-carboxaldehyde (STC-6)-from S. thunbergii and evaluated their inhibitory effects on adipocyte differentiation in 3T3-L1 cells. We found that STC-1 and STC-5 resulted in non-toxic inhibition of the differentiation of 3T3-L1 adipocytes and thus selected these compounds for further study. STC-1 and STC-5 significantly inhibited lipid accumulation and downregulated the expression of peroxisome proliferator-activated receptor-gamma (PPAR gamma), CCAAT/enhancer-binding protein alpha (C/EBP alpha), and sterol regulatory element-binding protein 1c (SREBP-1c) in a dose-dependent manner. The specific mechanism mediating the effects of STC-1 and STC-5 was shown to be AMP-activated protein kinase (AMPK) activation. Our results demonstrated the inhibitory effect of STC-1 and STC-5 on adipogenesis through the activation of the AMPK signal pathway. Together, these findings suggested that STC-1 and STC-5 may be effective candidates for the prevention of obesity or obesity-related diseases. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | ECKLONIA-CAVA | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | MECHANISMS | - |
dc.subject | SEAWEED | - |
dc.subject | DISEASE | - |
dc.subject | OBESITY | - |
dc.subject | CELLS | - |
dc.subject | DIECKOL | - |
dc.subject | MICE | - |
dc.title | Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes | - |
dc.type | Article | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 최윤경 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.15, no.4 | - |
dc.identifier.doi | 10.3390/md15040119 | - |
dc.identifier.scopusid | 2-s2.0-85018655104 | - |
dc.identifier.wosid | 000404228300035 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SEAWEED | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIECKOL | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | anti-obesity effect | - |
dc.subject.keywordAuthor | adipocyte | - |
dc.subject.keywordAuthor | Sargassum thunbergii | - |
dc.subject.keywordAuthor | indole derivatives | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |