Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages SCIE SCOPUS

Cited 13 time in WEB OF SCIENCE Cited 13 time in Scopus
Title
Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages
Author(s)
Choi, Youn Kyung; Ye, Bo-Ram; Kim, Eun-A; Kim, Junseong; Kim, Min-Sun; Lee, Won Woo; Ahn, Gin-Nae; Kang, Nalae; Jung, Won-Kyo; Heo, Soo-Jin
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2018-07
Abstract
Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can develop. Therefore, effective treatment before chronic inflammation development is essential. Bis (3-bromo-4,5-dihydroxybenzyl) ether (BBDE, C14H12Br2O5) is a novel bromophenol isolated from the red alga Polysiphonia morrowii. The beneficial physiological functions of various bromophenols are known, but whether BBDE has beneficial physiological functions is unknown. Therefore, we first investigated whether BBDE exerts any anti-inflammatory effect. We demonstrated that BBDE inhibits inflammation by reducing inflammatory mediators, such as nitric oxide, prostaglandin E2, iNOS, COX2, and pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6), in LPS-induced macrophage cells. To examine the mechanism of action by which BBDE inhibits inflammation, we confirmed its effect on signal transduction and ROS generation. BBDE selectively inhibited ERK phosphorylation in the mitogen-activated protein kinase pathways. Moreover BBDE suppressed LPS-induced ROS generation in RAW 264.7 macrophage cells. Inhibition of LPS-induced ROS generation by BBDE also caused ERK inactivation and an inflammatory reaction. Therefore, BBDE inhibits LPS-induced inflammation by inhibiting the ROS-mediated ERK signaling pathway in RAW 264.7 macrophage cells and thus can be useful for treating inflammatory diseases.
ISSN
0753-3322
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2103
DOI
10.1016/j.biopha.2018.04.121
Bibliographic Citation
BIOMEDICINE & PHARMACOTHERAPY, v.103, pp.1170 - 1177, 2018
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Subject
TOLL-LIKE RECEPTORS; NITRIC-OXIDE SYNTHASE; RHODOMELA-CONFERVOIDES; MOLECULAR-MECHANISMS; ANTIOXIDANT ACTIVITY; IL-12 PRODUCTION; TISSUE-INJURY; MAP KINASE; IN-VIVO; CELLS
Keywords
Bis (3-bromo-4,5-dihydroxybenzyl) ether; Inflammation; Macrophage; ROS/ERK
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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