유기주석화합물에 단기간 노출시킨 넙치 간장 약물대사효소의 in vivo 및 in vitro 반응 KCI OTHER

DC Field Value Language
dc.contributor.author 전중균 -
dc.contributor.author 이지선 -
dc.contributor.author 전미정 -
dc.contributor.author 심원준 -
dc.contributor.author 임한규 -
dc.date.accessioned 2020-04-19T23:42:55Z -
dc.date.available 2020-04-19T23:42:55Z -
dc.date.created 2020-02-10 -
dc.date.issued 2004-03 -
dc.identifier.issn 1226-9999 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/2013 -
dc.description.abstract Cytochrome P450 (CYP) contents and 7 -ethoxyresorufin -O -deethylase(EROD) activity were determined in hepatic microsome of olive flounder ( Paralichthysolivaceus ) exposed to tributyltin chloride (TBTC), tributyltin oxide (TBTO), andtriphenyltin chloride (TPTC). In addition, effects of in vivo (intraperitoneal injection of7.5mg kg-1 BW) exposure of flounder to TPTC on CYP, NADPH cytochrome c reductase,NADH cytochrome b5 reductase and EROD levels were measured. In in vitro exposureof hepatic microsome to organotins, TBTC, TBTO and TPTC reduced CYP contents andinhibited EROD activity. The TPTC was the strongest inhibitor, which is followed byTBTO and TBTC. The degree of inhibition, especially EROD acitivity, depended on theexposure duration. In addition, all the target enzymes in flounder were inhibited byTPTC with the in vivo exposure to TPTC. As EROD activity was the most sensitive tothe inhibitions and demonstrated good reproducibility of the results, it could be usedas a helpful tool for monitor effects of organotin compounds on mixed funcitonoxygenase system in marine fish. -
dc.description.uri 3 -
dc.publisher 한국환경생물학회 -
dc.title 유기주석화합물에 단기간 노출시킨 넙치 간장 약물대사효소의 in vivo 및 in vitro 반응 -
dc.title.alternative In viro and In vivo Responses of MFO systems in Olive Flounder (Paralichthys olivaceus) Exposed to TBT and TPT for Short-term Period -
dc.type Article -
dc.citation.endPage 183 -
dc.citation.startPage 177 -
dc.citation.title 환경생물 -
dc.citation.volume 22 -
dc.citation.number 1 -
dc.contributor.alternativeName 심원준 -
dc.identifier.bibliographicCitation 환경생물, v.22, no.1, pp.177 - 183 -
dc.identifier.kciid ART001158563 -
dc.description.journalClass 3 -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor flounder -
dc.subject.keywordAuthor in vivo -
dc.subject.keywordAuthor TBT -
dc.subject.keywordAuthor TPT -
dc.subject.keywordAuthor cytochrome P450 -
dc.subject.keywordAuthor EROD -
dc.subject.keywordAuthor NADPH cytochromec reductase -
dc.subject.keywordAuthor NADH cytochrome b5 reductase -
dc.description.journalRegisteredClass kci -
dc.description.journalRegisteredClass other -
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