Effects of 4-Nonlyphenol Exposure on P. olivaceus and S. schlegeli Vitellogenesis
KCI
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Title
- Effects of 4-Nonlyphenol Exposure on P. olivaceus and S. schlegeli Vitellogenesis
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Author(s)
- 정지현; Sun Hae Bae; Kyong Lan Baeck; Won Joon Shim; Dae-Jung Kim; Chang Hee Han
- KIOST Author(s)
- Jung, Jee Hyun(정지현); Shim, Won Joon(심원준)
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Alternative Author(s)
- 정지현; 심원준
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Publication Year
- 2012-03
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Abstract
- The effects of the estrogenic compound 4-nonylphenol (4-NP) on vitellogenesis in juvenile olive flounder ( Paralichthys olivaceus ) and rockfish ( Sebastes schlegeli ) exposed continuously at 10, 50 and 100μgℓ−1 levels for 7 days were compared. The expression of VTG mRNA level and protein using specific probes were examined. The levels of plasma estradiol-17 β(E2) and testosterone (T) were assessed by radioimmunoassay (RIA). Plasma E2 concentrations increased significantly in two female fish species exposed to 100μgℓ−1 of 4-NP over concentrations in control fish. Plasma T concentrations increased in P. olivaceus . Four days after exposure, the level of VTG mRNA expression increased in P. olivaceus and S. schlegeli exposed to 20μgℓ−1 of 4-NP. In addition, plasma VTG protein expression was seen in P. olivaceus and S. schlegeli . In S. schlegeli and P. olivaceus exposed to 4-NP, the changes were noticed mainly in hepatocytic vaculation after 7 days of exposure. Thus, 4-NP may disrupt vitellogenesis in immature fish both directly and indirectly via disrupted steroidogenesis and liver pathology. Immature S. schlegeli were the most sensitive to 4-NP exposure in vitellogenesis.
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ISSN
- 2465-9525
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1746
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Bibliographic Citation
- 발생과 생식, v.16, no.1, pp.9 - 18, 2012
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Publisher
- 한국발생생물학회
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Keywords
- Vitellogenin; Paralichthys olivaceus; Sebastes schlegeli; 4-Nonylphenol; Steroidogenesis; Endocrine disrupter
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Type
- Article
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Language
- English
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