Effects of 4-Nonlyphenol Exposure on P. olivaceus and S. schlegeli Vitellogenesis KCI

Title
Effects of 4-Nonlyphenol Exposure on P. olivaceus and S. schlegeli Vitellogenesis
Author(s)
정지현; Sun Hae Bae; Kyong Lan Baeck; Won Joon Shim; Dae-Jung Kim; Chang Hee Han
KIOST Author(s)
Jung, Jee Hyun(정지현)Shim, Won Joon(심원준)
Publication Year
2012-03
Abstract
The effects of the estrogenic compound 4-nonylphenol (4-NP) on vitellogenesis in juvenile olive flounder ( Paralichthys olivaceus ) and rockfish ( Sebastes schlegeli ) exposed continuously at 10, 50 and 100μgℓ−1 levels for 7 days were compared. The expression of VTG mRNA level and protein using specific probes were examined. The levels of plasma estradiol-17 β(E2) and testosterone (T) were assessed by radioimmunoassay (RIA). Plasma E2 concentrations increased significantly in two female fish species exposed to 100μgℓ−1 of 4-NP over concentrations in control fish. Plasma T concentrations increased in P. olivaceus . Four days after exposure, the level of VTG mRNA expression increased in P. olivaceus and S. schlegeli exposed to 20μgℓ−1 of 4-NP. In addition, plasma VTG protein expression was seen in P. olivaceus and S. schlegeli . In S. schlegeli and P. olivaceus exposed to 4-NP, the changes were noticed mainly in hepatocytic vaculation after 7 days of exposure. Thus, 4-NP may disrupt vitellogenesis in immature fish both directly and indirectly via disrupted steroidogenesis and liver pathology. Immature S. schlegeli were the most sensitive to 4-NP exposure in vitellogenesis.
ISSN
2465-9525
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1746
Bibliographic Citation
발생과 생식, v.16, no.1, pp.9 - 18, 2012
Publisher
한국발생생물학회
Keywords
Vitellogenin; Paralichthys olivaceus; Sebastes schlegeli; 4-Nonylphenol; Steroidogenesis; Endocrine disrupter
Type
Article
Language
English
Publisher
한국발생생물학회
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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