FGF11 induced by hypoxia interacts with HIF-1 alpha and enhances its stability SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 4 time in Scopus
Title
FGF11 induced by hypoxia interacts with HIF-1 alpha and enhances its stability
Author(s)
Lee, Kyeong Won; Yim, Hyung-Soon; Shin, Jihye; Lee, Cheolju; Lee, Jung-Hyun; Jeong, Jae-Yeon
KIOST Author(s)
Lee, Kyeong Won(이경원)Yim, Hyung Soon(임형순)Lee, Jung Hyun(이정현)
Publication Year
2017-01
Abstract
Fibroblast growth factor 11 (FGF11) is an intracellular FGF. Although induction of FGF11 by hypoxia has been observed in several cell types, the molecular function of FGF11 is not clearly understood yet. Here, we investigated the role of FGF11 under hypoxia. We identified hypoxia-inducible factor-1 alpha (HIF-1 alpha) as an interacting protein of FGF11 using immunoprecipitation and mass spectrometry. FGF11 knockdown decreased HIF-1 alpha protein, while FGF11 overexpression increased it, without affecting HIF-1 alpha mRNA. Protein stability test and ubiquitination assay showed that FGF11 increased HIF-1 alpha stability by acting upstream of proteasomal degradation. Altogether, these results suggest a cross-regulation between HIF-1a and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1 alpha.
ISSN
1873-3468
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1311
DOI
10.1002/1873-3468.12547
Bibliographic Citation
FEBS LETTERS, v.591, no.2, pp.348 - 357, 2017
Publisher
WILEY
Subject
FACTOR HOMOLOGOUS FACTORS; INDUCIBLE FACTORS; EXPRESSION; CANCER; CELLS; INDUCTION; EVOLUTION; THERAPY; PROTEIN
Keywords
FGF11; HIF-1 alpha; hypoxia; intracellular fibroblast growth factor
Type
Article
Language
English
Document Type
Article
Publisher
WILEY
Related Researcher
Research Interests

marine biotechnology,molecular microbiology,해양생명공학,분자미생물학

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