Identification and large isolation of an anti-inflammatory compound from an edible brown seaweed, Undariopsis peterseniana, and evaluation on its anti-inflammatory effect in in vitro and in vivo zebrafish SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Hyeok | - |
dc.contributor.author | Ko, Ju-Young | - |
dc.contributor.author | Kim, Eun-A | - |
dc.contributor.author | Hwang, Eun-Kyoung | - |
dc.contributor.author | Park, Chan Sun | - |
dc.contributor.author | Lee, Jung-Suck | - |
dc.contributor.author | Kim, Chul-Young | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.contributor.author | Kang, Hee-Kyoung | - |
dc.contributor.author | Cha, Seon-Heui | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2020-04-16T10:40:09Z | - |
dc.date.available | 2020-04-16T10:40:09Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0921-8971 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/1233 | - |
dc.description.abstract | In this study, we isolated and purified secondary metabolites from an edible brown seaweed, Undariopsis peterseniana, and evaluated their anti-inflammatory effects in vitro and in vivo. Apo-9'-fucoxanthinone (Apo-9'), a main anti-inflammatory compound found in the chloroform fraction of U. peterseniana extracts, was first isolated by one-step centrifugal partition chromatography and identified by nuclear magnetic resonance. Apo-9' significantly decreased nitric oxide (NO), prostaglandin E-2, pro-inflammatory proteins (inducible NO synthase [iNOS] and cyclooxygenase [COX-2]), and pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells without exhibiting any cytotoxicity. In vivo, Apo-9' protected LPS-stimulated zebrafish embryos against inflammatory stress and suppressed the expression of pro-inflammatory proteins such as COX-2 and iNOS. These findings suggest that U. peterseniana extract and Apo-9' could be used as an anti-inflammatory agent in health care. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | INDUCED INFLAMMATORY RESPONSE | - |
dc.subject | CENTRIFUGAL PARTITION CHROMATOGRAPHY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | PREPARATIVE ISOLATION | - |
dc.subject | ECKLONIA-CAVA | - |
dc.subject | ALGA | - |
dc.subject | EXTRACT | - |
dc.subject | PHLOROTANNINS | - |
dc.subject | PURIFICATION | - |
dc.subject | FRACTION | - |
dc.title | Identification and large isolation of an anti-inflammatory compound from an edible brown seaweed, Undariopsis peterseniana, and evaluation on its anti-inflammatory effect in in vitro and in vivo zebrafish | - |
dc.type | Article | - |
dc.citation.endPage | 1596 | - |
dc.citation.startPage | 1587 | - |
dc.citation.title | JOURNAL OF APPLIED PHYCOLOGY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | JOURNAL OF APPLIED PHYCOLOGY, v.29, no.3, pp.1587 - 1596 | - |
dc.identifier.doi | 10.1007/s10811-016-1012-3 | - |
dc.identifier.scopusid | 2-s2.0-84997017911 | - |
dc.identifier.wosid | 000401429300047 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDUCED INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | CENTRIFUGAL PARTITION CHROMATOGRAPHY | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PREPARATIVE ISOLATION | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | ALGA | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PHLOROTANNINS | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | FRACTION | - |
dc.subject.keywordAuthor | Phaeophyceae, centrifugal partition chromatography | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Apo-9 &apos | - |
dc.subject.keywordAuthor | -fucoxanthinone | - |
dc.subject.keywordAuthor | RAW 264.7 cell line | - |
dc.subject.keywordAuthor | Zebrafish | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |