Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice
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Title
- Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice
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Author(s)
- Koh, Eun-Jeong; Seo, Young-Jin; Choi, Jia; Lee, Hyeon Yong; Kang, Do-Hyung; Kim, Kui-Jin; Lee, Boo-Yong
- KIOST Author(s)
- Kang, Do Hyung(강도형)
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Alternative Author(s)
- 강도형
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Publication Year
- 2017-08
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Abstract
- Spirulina maxima is a microalgae which contains flavonoids and other polyphenols. Although Spirulina maxima 70% ethanol extract (SM70EE) has diverse beneficial effects, its effects on neurotoxicity have not been fully understood. In this study, we investigated the neuroprotective effects of SM70EE against trimethyltin (TMT)-induced neurotoxicity in HT-22 cells. SM70EE inhibited the cleavage of poly-ADP ribose polymerase (PARP). Besides, ROS production was decreased by down-regulating oxidative stress-associated enzymes. SM70EE increased the factors of brain-derived neurotrophic factor (BDNF)/cyclic AMP-responsive element-binding protein (CREB) signalling pathways. Additionally, acetylcholinesterase (AChE) was suppressed by SM70EE. Furthermore, we investigated whether SM70EE prevents cognitive deficits against scopolamine-induced neurotoxicity in mice by applying behavioral tests. SM70EE increased step-through latency time and decreased the escape latency time. Therefore, our data suggest that SM70EE may prevent TMT neurotoxicity through promoting activation of BDNF/CREB neuroprotective signaling pathways in neuronal cells. In vivo study, SM70EE would prevent cognitive deficits against scopolamine-induced neurotoxicity in mice.
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ISSN
- 1420-3049
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1181
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DOI
- 10.3390/molecules22081363
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Bibliographic Citation
- MOLECULES, v.22, no.8, 2017
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Publisher
- MDPI AG
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Subject
- SCOPOLAMINE-INDUCED AMNESIA; OXIDATIVE STRESS; CHOLINERGIC HYPOTHESIS; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; MESSENGER-RNA; PC12 CELLS; BRAIN; ACETYLCHOLINESTERASE; MICROALGAE
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Keywords
- Spirulina maxima 70% ethanol extract (SM70EE); trimethyltin (TMT); neurotoxicity; acetylcholinesterase (AChE); cognitive deficits
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Type
- Article
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Language
- English
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Document Type
- Article
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