Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Koh, Eun-Jeong | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Choi, Jia | - |
dc.contributor.author | Lee, Hyeon Yong | - |
dc.contributor.author | Kang, Do-Hyung | - |
dc.contributor.author | Kim, Kui-Jin | - |
dc.contributor.author | Lee, Boo-Yong | - |
dc.date.accessioned | 2020-04-16T10:25:10Z | - |
dc.date.available | 2020-04-16T10:25:10Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/1181 | - |
dc.description.abstract | Spirulina maxima is a microalgae which contains flavonoids and other polyphenols. Although Spirulina maxima 70% ethanol extract (SM70EE) has diverse beneficial effects, its effects on neurotoxicity have not been fully understood. In this study, we investigated the neuroprotective effects of SM70EE against trimethyltin (TMT)-induced neurotoxicity in HT-22 cells. SM70EE inhibited the cleavage of poly-ADP ribose polymerase (PARP). Besides, ROS production was decreased by down-regulating oxidative stress-associated enzymes. SM70EE increased the factors of brain-derived neurotrophic factor (BDNF)/cyclic AMP-responsive element-binding protein (CREB) signalling pathways. Additionally, acetylcholinesterase (AChE) was suppressed by SM70EE. Furthermore, we investigated whether SM70EE prevents cognitive deficits against scopolamine-induced neurotoxicity in mice by applying behavioral tests. SM70EE increased step-through latency time and decreased the escape latency time. Therefore, our data suggest that SM70EE may prevent TMT neurotoxicity through promoting activation of BDNF/CREB neuroprotective signaling pathways in neuronal cells. In vivo study, SM70EE would prevent cognitive deficits against scopolamine-induced neurotoxicity in mice. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | CHOLINERGIC HYPOTHESIS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | MEMORY IMPAIRMENT | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | PC12 CELLS | - |
dc.subject | BRAIN | - |
dc.subject | ACETYLCHOLINESTERASE | - |
dc.subject | MICROALGAE | - |
dc.title | Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of BDNF/CREB Signaling Pathways in Neuronal Cells and Mice | - |
dc.type | Article | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.contributor.alternativeName | 강도형 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.22, no.8 | - |
dc.identifier.doi | 10.3390/molecules22081363 | - |
dc.identifier.scopusid | 2-s2.0-85027975162 | - |
dc.identifier.wosid | 000408602900126 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CHOLINERGIC HYPOTHESIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | MEMORY IMPAIRMENT | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
dc.subject.keywordPlus | MICROALGAE | - |
dc.subject.keywordAuthor | Spirulina maxima 70% ethanol extract (SM70EE) | - |
dc.subject.keywordAuthor | trimethyltin (TMT) | - |
dc.subject.keywordAuthor | neurotoxicity | - |
dc.subject.keywordAuthor | acetylcholinesterase (AChE) | - |
dc.subject.keywordAuthor | cognitive deficits | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |