Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 14 time in Scopus
Title
Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells
Author(s)
Cha, Seon-Heui; Hwang, Yongha; Heo, Soo-Jin; Jun, Hee-Sook
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2018
Abstract
Diabetic nephropathy is the leading cause of end-stage renal disease in patients with diabetes mellitus. Oxidative stress has been shown to play an important role in pathogeneses of renal damage in diabetic patients. Here, we investigated the protective effect of diphlorethohydroxycarmalol (DPHC), which is a polyphenol isolated from an edible seaweed, Ishige okamurae, on methylglyoxal-induced oxidative stress in HEK cells, a human embryonic kidney cell line. DPHC treatment inhibited methylglyoxal-(MGO-) induced cytotoxicity and ROS production. DPHC activated the Nrf2 transcription factor and increased the mRNA expression of antioxidant and detoxification enzymes, consequently reducing MGO-induced advanced glycation end product formation. In addition, DPHC increased glyoxalase-1 mRNA expression and attenuated MGO-induced advanced glycation end product formation in HEK cells. These results suggest that DPHC possesses a protective activity against MGO-induced cytotoxicity in human kidney cells by preventing oxidative stress and advanced glycation end product formation. Therefore, it could be used as a potential therapeutic agent for the prevention of diabetic nephropathy.
ISSN
1942-0900
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1071
DOI
10.1155/2018/3654095
Bibliographic Citation
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018
Publisher
HINDAWI LTD
Subject
ISHIGE-OKAMURAE; NATURAL-PRODUCTS; GLYOXALASE 1; NRF2; ANTIOXIDANT; HYPERGLYCEMIA; POLYPHENOLS; MECHANISMS; DISEASE; PATHOGENESIS
Type
Article
Language
English
Document Type
Article
Publisher
HINDAWI LTD
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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